Document Detail

A semicompartmental modeling approach for pharmacodynamic data assessment.
MedLine Citation:
PMID:  8834198     Owner:  NLM     Status:  MEDLINE    
A new method is proposed for modeling the temporal aspects of the pharmacodynamic-pharmacokinetic relationship of drugs. A semicompartmental solution to the effect-site link model of Sheiner et al. (1) formed the basis for this new approach. This semicompartmental solution does not require the specification of a compartmental model for the pharmacokinetic response and may offer an advantage when model misspecification is present in using standard compartmental models. A Monte Carlo simulation study was conducted to evaluate the performance of the semicompartmental modeling approach. This method is easily implemented in standard nonlinear regression packages.
K G Kowalski; A Karim
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Publication Detail:
Type:  Clinical Trial; Journal Article    
Journal Detail:
Title:  Journal of pharmacokinetics and biopharmaceutics     Volume:  23     ISSN:  0090-466X     ISO Abbreviation:  J Pharmacokinet Biopharm     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1996-11-27     Completed Date:  1996-11-27     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0357115     Medline TA:  J Pharmacokinet Biopharm     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  307-22     Citation Subset:  IM    
Department of Statistics and Clinical Data Management, Searle Research and Development, Skokie, Illinois 60077, USA.
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MeSH Terms
Anti-Arrhythmia Agents / administration & dosage,  pharmacokinetics
Infusions, Intravenous
Models, Biological
Monte Carlo Method
Nonlinear Dynamics
Piperidines / administration & dosage,  pharmacokinetics
Regression Analysis
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Piperidines; 103810-45-3/bidisomide

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