Document Detail

A self-protecting servo-model for explanation of the mechanism involved in spontaneous ventricular defibrillation.
MedLine Citation:
PMID:  8664244     Owner:  NLM     Status:  MEDLINE    
Ventricular fibrillation (VF) is the most life-threatening arrhythmia. It has been suggested that VF in humans is always sustained. Recent publications indicated that VF can be either sustained (SVF) or transient (TVF), reverting spontaneously into sinus rhythm. In previous studies we have hypothesized that TVF requires, during VF, a high cardiac catecholamine level ([CA]). Since during VF sympathetic activity is enhanced, the question arises of why VF is sustained in the majority of cases. Looking on the living body as a self-protecting servo-mechanism, we propose a servo-model that on the one hand describes the mechanism involved in TVF and on the other proposes a therapeutic procedure which can help the heart in its effort to transform VF into TVF. Our model has been examined by various experimental studies. The results obtained strongly support our hypothesis.
M Manoach; D Varon; M Erez
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of basic and clinical physiology and pharmacology     Volume:  4     ISSN:  0792-6855     ISO Abbreviation:  J Basic Clin Physiol Pharmacol     Publication Date:    1993 Oct-Dec
Date Detail:
Created Date:  1996-08-07     Completed Date:  1996-08-07     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9101750     Medline TA:  J Basic Clin Physiol Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  273-80     Citation Subset:  IM    
Department of Physiology and Pharmacology, Sackler School of Medicine, Tel-Aviv, Israel.
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MeSH Terms
Catecholamines / metabolism
Models, Biological*
Ventricular Fibrillation / metabolism*
Reg. No./Substance:

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