Document Detail


The self-destructive personality of a cell cycle in transition.
MedLine Citation:
PMID:  8608008     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The transition from G1 to S phase, sister chromatid separation in anaphase, and the exit from mitosis are driven by the destruction of cell cycle regulatory proteins by distinct ubiquitin-dependent proteolytic pathways. The components and targets of these key degradation pathways are now becoming clear. Genetic and biochemical dissections of these extremely specific and well regulated destruction pathways are providing fundamental insights into the mechanisms of control of the cell division cycle.
Authors:
R J Deshaies
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Current opinion in cell biology     Volume:  7     ISSN:  0955-0674     ISO Abbreviation:  Curr. Opin. Cell Biol.     Publication Date:  1995 Dec 
Date Detail:
Created Date:  1996-05-28     Completed Date:  1996-05-28     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8913428     Medline TA:  Curr Opin Cell Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  781-9     Citation Subset:  IM    
Affiliation:
Division of Biology, California Institute of Technology, Pasadena 91125, USA. deshaiesr@starbase1.caltech.edu
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MeSH Terms
Descriptor/Qualifier:
Cell Cycle / physiology*
Yeasts / cytology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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