| A self-associating protein critical for chromosome attachment, division, and polar organization in caulobacter. | |
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MedLine Citation:
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PMID: 18805089 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Cell polarization is an integral part of many unrelated bacterial processes. How intrinsic cell polarization is achieved is poorly understood. Here, we provide evidence that Caulobacter crescentus uses a multimeric pole-organizing factor (PopZ) that serves as a hub to concurrently achieve several polarizing functions. During chromosome segregation, polar PopZ captures the ParB*ori complex and thereby anchors sister chromosomes at opposite poles. This step is essential for stabilizing bipolar gradients of a cell division inhibitor and setting up division near midcell. PopZ also affects polar stalk morphogenesis and mediates the polar localization of the morphogenetic and cell cycle signaling proteins CckA and DivJ. Polar accumulation of PopZ, which is central to its polarizing activity, can be achieved independently of division and does not appear to be dictated by the pole curvature. Instead, evidence suggests that localization of PopZ largely relies on PopZ multimerization in chromosome-free regions, consistent with a self-organizing mechanism. |
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Authors:
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Gitte Ebersbach; Ariane Briegel; Grant J Jensen; Christine Jacobs-Wagner |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Cell Volume: 134 ISSN: 1097-4172 ISO Abbreviation: Cell Publication Date: 2008 Sep |
Date Detail:
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Created Date: 2008-09-22 Completed Date: 2008-10-09 Revised Date: 2011-03-08 |
Medline Journal Info:
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Nlm Unique ID: 0413066 Medline TA: Cell Country: United States |
Other Details:
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Languages: eng Pagination: 956-68 Citation Subset: IM |
Affiliation:
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Department of Molecular, Cellular and Developmental Biology, Yale University, New Haven, CT 06520, USA. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Bacterial Proteins
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metabolism* Caulobacter crescentus / cytology*, metabolism* Chromosomes, Bacterial / metabolism* DNA Replication Escherichia coli / metabolism Replication Origin |
| Grant Support | |
ID/Acronym/Agency:
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AI067548/AI/NIAID NIH HHS; GM065835/GM/NIGMS NIH HHS; R01 GM065835-05/GM/NIGMS NIH HHS; //Howard Hughes Medical Institute |
| Chemical | |
Reg. No./Substance:
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0/Bacterial Proteins; 0/chromosome partition proteins, bacterial |
| Comments/Corrections | |
Comment In:
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Cell. 2008 Sep 19;134(6):916-8
[PMID:
18805084
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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