| A self-assembled nanodelivery system enhances the oral bioavailability of daidzein: in vitro characteristics and in vivo performance. | |
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MedLine Citation:
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PMID: 22026378 Owner: NLM Status: In-Data-Review |
Abstract/OtherAbstract:
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Aim: A self-assembled nano-based delivery system was designed and developed to increase the oral bioavailability of poor hydrophilic and lipophilic daidzein. Methods: Daidzein was firstly combined with lecithin to form the daidzein-lecithin complex, then self-assembled into micelles (DLMs) with lecithin and sodium bile. The physiochemical properties and intestinal absorption of DLMs were characterized, and the pharmacokinetic behavior was evaluated in rats. Results: DLMs exhibited nanometer-sized particles. DLMs were mainly distributed in the stomach and proximal intestine after oral administration. The intestinal absorption of DLMs was significantly improved, and DLMs could be absorbed via both endocytosis and passive transport. The AUC(0-t) value of daidzein in rats treated with DLMs was ninefold greater than that of free daidzein suspension. Conclusion: The presented delivery system could provide a new promising strategy for enhancing the oral bioavailability of drugs with poor hydrophilicity and lipophilicity. Original submitted: 3/10/2010; Revised submitted: 22/12/2010. |
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Authors:
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Zhiwen Zhang; Yan Huang; Fang Gao; Zhiwei Gao; Huihui Bu; Wangwen Gu; Yaping Li |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Nanomedicine (London, England) Volume: 6 ISSN: 1748-6963 ISO Abbreviation: Nanomedicine (Lond) Publication Date: 2011 Oct |
Date Detail:
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Created Date: 2011-10-26 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101278111 Medline TA: Nanomedicine (Lond) Country: England |
Other Details:
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Languages: eng Pagination: 1365-79 Citation Subset: IM |
Affiliation:
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Shanghai Institute of Materia Medica, Chinese Academy of Sciences, Shanghai 201203, China. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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