Document Detail


A selective increase in circulating inhibin and inhibin pro-alphaC at the time of ovulation in the mare.
MedLine Citation:
PMID:  10567014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The relationship between a selective increase in circulating immunoreactive (ir)-inhibin and the time of ovulation was investigated in mares. Concentrations of plasma ir-inhibin were measured every 4 h during the periovulatory period. Inhibin pro-alphaC, a precursor protein of the inhibin alpha-subunit, was also measured. The changes in ir-inhibin and inhibin pro-alphaC in circulation were parallel. Concentrations of both ir-inhibin and inhibin pro-alphaC in the plasma increased at the same time when ovulatory follicles ruptured, and the peak levels of circulating ir-inhibin and inhibin pro-alphaC were maintained for 4-8 h. There was no selective increase in plasma concentrations of estradiol-17beta during the process of ovulation. These results suggest that the selective increase in ir-inhibin and inhibin pro-alphaC was caused by the absorption of follicular fluid after the rupture of ovulatory follicles. These results also suggest that the measuring of plasma concentrations of ir-inhibin or inhibin pro-alphaC in mares might be a useful method for detecting the time of ovulation.
Authors:
K Nagaoka; Y Nambo; N Nagamine; S I Nagata; Y Tanaka; H Shinbo; N Tsunoda; H Taniyama; G Watanabe; N P Groome; K Taya
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The American journal of physiology     Volume:  277     ISSN:  0002-9513     ISO Abbreviation:  Am. J. Physiol.     Publication Date:  1999 Nov 
Date Detail:
Created Date:  1999-12-14     Completed Date:  1999-12-14     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0370511     Medline TA:  Am J Physiol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  E870-5     Citation Subset:  IM    
Affiliation:
Laboratory of Veterinary Physiology, Tokyo University of Agriculture and Technology, Tokyo 183-8509, Japan.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Markers
Breeding
Enzyme-Linked Immunosorbent Assay / methods
Female
Follicle Stimulating Hormone / blood
Horses / physiology*
Inhibins / analysis,  blood*
Luteinizing Hormone / blood
Ovulation / physiology*
Progesterone / blood
Protein Precursors / analysis,  blood*
Radioimmunoassay
Chemical
Reg. No./Substance:
0/Biological Markers; 0/Protein Precursors; 0/inhibin-alpha subunit precursor; 57-83-0/Progesterone; 57285-09-3/Inhibins; 9002-67-9/Luteinizing Hormone; 9002-68-0/Follicle Stimulating Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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