Document Detail

The selective anticancer agent pb-100 inhibits interleukin-6 induced enhancement of glioblastoma cell-proliferation in-vitro.
MedLine Citation:
PMID:  21559655     Owner:  NLM     Status:  In-Data-Review    
The multifunctional cytokine interleukin-6 behaves as a growth factor for various malignancies. It is produced in significant amounts by glioblastoma cells. When exogenous IL-6 is added (pg/ml) to culture medium of human glioblastoma cells and normal (non malignant) astrocytes used as controls, it exerts a dose dependent and differential effect on these two cell lines. Enhancement of cell proliferation is twice as high for glioblastoma cells as for astrocytes. In vitro, the novel anticancer agent PB-100 (mu g/ml) dose dependently inhibits this stimulatory activity. In addition, increasing PB-100 concentrations finally induce death of the malignant cells, yet do not impede multiplication of normal astrocytes. PB-100 does not abolish IL-6 production by cells, but keeps its level down to physiological values. PB-100 should therefore find its place in therapies requiring control of IL-6 production.
M Beljanski; S Crochet
Related Documents :
21468425 - Systematic proteomic analysis of human hepotacellular carcinoma cells reveals molecular...
25435975 - Polyamine analog tbp inhibits proliferation of human k562 chronic myelogenous leukemia ...
4655665 - Finite difference solution for biopotentials of axially symmetric cells.
25226385 - Trophic activity of human p2x7 receptor isoforms a and b in osteosarcoma.
10645975 - Target cell contact suppresses neurite outgrowth from soma-soma paired lymnaea neurons.
227855 - Paraquat and escherichia coli. mechanism of production of extracellular superoxide radi...
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  International journal of oncology     Volume:  5     ISSN:  1019-6439     ISO Abbreviation:  Int. J. Oncol.     Publication Date:  1994 Oct 
Date Detail:
Created Date:  2011-05-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9306042     Medline TA:  Int J Oncol     Country:  Greece    
Other Details:
Languages:  eng     Pagination:  873-9     Citation Subset:  -    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Influence of different promoters on the expression of tumor-necrosis-factor-alpha in ls174t human co...
Next Document:  Reliability of immunoradiometric assays for sex-hormone binding globulin, androstenedione, 17-Beta e...