| A secondary progressive clinical course is uncommon in neuromyelitis optica. | |
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MedLine Citation:
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PMID: 17310032 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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We compared the clinical course of 96 patients with neuromyelitis optica (NMO) to multiple sclerosis (MS) natural history data. Based on the distribution of follow-up data (median 6.1 year), we estimated that 21 NMO patients would convert to a secondary progressive course, but we observed only two conversions (p = 0.00002; relative risk = 0.08). The disparate natural histories of MS and NMO suggest dissociation between relapses and clinical progression in CNS demyelinating diseases. |
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Authors:
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D M Wingerchuk; S J Pittock; C F Lucchinetti; V A Lennon; B G Weinshenker |
Publication Detail:
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Type: Comparative Study; Journal Article |
Journal Detail:
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Title: Neurology Volume: 68 ISSN: 1526-632X ISO Abbreviation: Neurology Publication Date: 2007 Feb |
Date Detail:
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Created Date: 2007-02-20 Completed Date: 2007-03-21 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0401060 Medline TA: Neurology Country: United States |
Other Details:
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Languages: eng Pagination: 603-5 Citation Subset: AIM; IM |
Affiliation:
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Department of Neurology, Mayo Clinic College of Medicine, 13400 East Shea Boulevard, Scottsdale, AZ 85259, USA. wingerchuk.dean@mayo.edu |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Cohort Studies Disease Progression Female Humans Incidence Male Middle Aged Multiple Sclerosis, Chronic Progressive / epidemiology*, physiopathology* Muscle Weakness / epidemiology, physiopathology Muscle, Skeletal / innervation, physiopathology Neuromyelitis Optica / epidemiology*, physiopathology* Optic Nerve / immunology, pathology, physiopathology Recurrence Vision, Low / epidemiology, physiopathology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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