| Second lineage of heart forming region provides new understanding of conotruncal heart defects. | |
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MedLine Citation:
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PMID: 20050864 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Abnormal heart development causes various congenital heart defects. Recent cardiovascular biology studies have elucidated the morphological mechanisms involved in normal and abnormal heart development. The primitive heart tube originates from the lateral-most part of the heart forming mesoderm and mainly gives rise to the left ventricle. Then, during the cardiac looping, the outflow tract is elongated by the addition of cardiogenic cells from the both pharyngeal and splanchnic mesoderm (corresponding to anterior and secondary heart field, respectively), which originate from the mediocaudal region of the heart forming mesoderm and are later located anteriorly (rostrally) to the dorsal region of the heart tube. Therefore, the heart progenitors that contribute to the outflow tract region are distinct from those that form the left ventricle. The knowledge that there are two different lineages of heart progenitors in the four-chambered heart provides new understanding of the morphological and molecular etiology of conotruncal heart defects. |
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Authors:
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Yuji Nakajima |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't; Review Date: 2009-12-24 |
Journal Detail:
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Title: Congenital anomalies Volume: 50 ISSN: 1741-4520 ISO Abbreviation: Congenit Anom (Kyoto) Publication Date: 2010 Mar |
Date Detail:
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Created Date: 2010-03-05 Completed Date: 2010-05-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9306292 Medline TA: Congenit Anom (Kyoto) Country: Japan |
Other Details:
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Languages: eng Pagination: 8-14 Citation Subset: IM |
Affiliation:
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Department of Anatomy and Cell Biology, Osaka City University, Japan. yuji@med.osaka-cu.ac.jp |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Cell Lineage* Gene Expression Regulation, Developmental Heart / embryology* Heart Defects, Congenital / embryology* Heart Ventricles / embryology Humans Infant, Newborn Mesoderm / cytology Transposition of Great Vessels / embryology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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