Document Detail


The search for unaffected individuals with Lynch syndrome: do the ends justify the means?
MedLine Citation:
PMID:  21205737     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Lynch syndrome is the most common cause of inherited colorectal and endometrial cancers yet it is underrecognized in clinical practice. The relative merits of screening for Lynch syndrome among healthy adults without cancer versus among adults with colorectal or endometrial cancer are discussed in this Perspective article. Newly diagnosed colorectal cancer patients are a much easier target population for screening and this approach leads to more informative genetic test results, at a lower cost in most cases.
Authors:
Heather Hampel; Albert de la Chapelle
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Cancer prevention research (Philadelphia, Pa.)     Volume:  4     ISSN:  1940-6215     ISO Abbreviation:  Cancer Prev Res (Phila)     Publication Date:  2011 Jan 
Date Detail:
Created Date:  2011-01-05     Completed Date:  2011-04-28     Revised Date:  2013-07-03    
Medline Journal Info:
Nlm Unique ID:  101479409     Medline TA:  Cancer Prev Res (Phila)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-5     Citation Subset:  IM    
Copyright Information:
©2011 AACR.
Affiliation:
Division of Human Genetics, Department of Internal Medicine, The Ohio State University Comprehensive Cancer Center, 2001 Polaris Parkway, Columbus, OH 43240, USA. Heather.Hampel@osumc.edu
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MeSH Terms
Descriptor/Qualifier:
Adult
Colorectal Neoplasms, Hereditary Nonpolyposis / diagnosis*,  genetics,  prevention & control
Genetic Predisposition to Disease
Genetic Testing
Humans
Pedigree
Prognosis
Risk Assessment
Grant Support
ID/Acronym/Agency:
CA16058/CA/NCI NIH HHS; CA67941/CA/NCI NIH HHS; R01 CA067941/CA/NCI NIH HHS; R01 CA067941-09/CA/NCI NIH HHS
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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