Document Detail


A search for specific and common susceptibility loci for schizophrenia and bipolar disorder: a linkage study in 13 target chromosomes.
MedLine Citation:
PMID:  11673797     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report the first stage of a genome scan of schizophrenia (SZ) and bipolar disorder (BP) covering 18 candidate chromosomal areas. In addition to testing susceptibility loci that are specific to each disorder, we tested the hypothesis that some susceptibility loci might be common to both disorders. A total of 480 individuals from 21 multigenerational pedigrees of Eastern Québec were evaluated by means of a consensus best-estimate diagnosis made blind to diagnoses in relatives and were genotyped with 220 microsatellite markers. Two-point and multipoint model-based linkage analyses were performed and mod scores (Z, for max Z(max)) are reported. The strongest linkage signals were detected at D18S1145 (in 18q12; Z = 4.03) for BP, and at D6S334 (in 6p 22-24; Z(het) = 3.47; alpha = 0.66) for SZ. Three other chromosomal areas (3q, 10p, and 21q) yielded linkage signals. Chromosomes 3p, 4p, 5p, 5q, 6q, 8p, 9q, 11q, 11p, 12q, 13q, 18p and 22q showed no evidence of linkage. The 18q12 results met the Lander and Kruglyak (1995) criterion for a genome-wide significant linkage and suggested that this susceptibility region may be shared by SZ and BP. The 6p finding provided confirmatory evidence of linkage for SZ. Our results suggest that both specific and common susceptibility loci must be searched for SZ and BP.
Authors:
M Maziade; M A Roy; E Rouillard; L Bissonnette; J P Fournier; A Roy; Y Garneau; N Montgrain; A Potvin; D Cliche; C Dion; H Wallot; A Fournier; L Nicole; J C Lavallée; C Mérette
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Molecular psychiatry     Volume:  6     ISSN:  1359-4184     ISO Abbreviation:  Mol. Psychiatry     Publication Date:  2001 Nov 
Date Detail:
Created Date:  2001-10-23     Completed Date:  2002-01-23     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607835     Medline TA:  Mol Psychiatry     Country:  England    
Other Details:
Languages:  eng     Pagination:  684-93     Citation Subset:  IM    
Affiliation:
Centre de Recherche Université Laval Robert-Giffard, 2601, chemin de la Canardière, Beauport (Québec) G1J 2G3, Canada. michel.maziade@psa.ulaval.ca
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MeSH Terms
Descriptor/Qualifier:
Adult
Bipolar Disorder / genetics*
Chromosomes
Family Health
Female
Genetic Predisposition to Disease
Genotype
Humans
Lod Score*
Male
Microsatellite Repeats
Middle Aged
Phenotype
Quebec
Schizophrenia / genetics*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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