Document Detail

The search for a practice model to reduce miscarriage after assisted reproduction.
MedLine Citation:
PMID:  22136961     Owner:  NLM     Status:  In-Data-Review    
The analysis of 52,874 clinical pregnancies recorded on the Australian and New Zealand Assisted Reproduction Database (ANZARD) between 2004 and 2008 showed that maternal age and obstetrics history are closely related to the risk of miscarriage, and that the transfer of fresh embryos is associated with fewer miscarriages than transfer of frozen-thawed embryos. It also suggested a higher miscarriage rate is associated with the transfer of thawed blastocysts compared with transfer of thawed cleavage-stage embryos or the blastocysts that ensued from them. Therefore, the authors proposed a practice model of transferring fresh blastocysts and freezing of cleavage-stage embryos to reduce the miscarriage rate after assisted reproduction. This model may have practical limitation and would need validation in a randomized trial. Retrospective analysis of large national databases is useful in identifying trends and generating hypothesis, but evaluation of these hypotheses in randomized trials remains necessary for objective validation.
Yakoub Khalaf; Tarek El-Toukhy
Publication Detail:
Type:  Journal Article     Date:  2011-10-08
Journal Detail:
Title:  Reproductive biomedicine online     Volume:  23     ISSN:  1472-6491     ISO Abbreviation:  Reprod. Biomed. Online     Publication Date:  2011 Dec 
Date Detail:
Created Date:  2011-12-05     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101122473     Medline TA:  Reprod Biomed Online     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  695-6     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Reproductive Healthcare Ltd. Published by Elsevier Ltd. All rights reserved.
Assisted Conception Unit and Centre for Pre-implantation Genetic Diagnosis, London, UK; Kings Health Partners, Women's Services, Guy's and St Thomas' NHS Foundation Trust, London, UK.
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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