Document Detail

The search for new drugs in the group of xanthine derivatives. XXXIX - Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines.
MedLine Citation:
PMID:  1193233     Owner:  NLM     Status:  MEDLINE    
Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines in n-butanol n-propanol DMF medium brought up a good yield of the corresponding trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-derivatives (I - III). The products (VII - IX), (XII), (XIII) were formed by nucleophilic displacement of the halogen of (II) or (III) by alkoxides or cyclamines. Acid hydrolysis of the alkoxy derivatives (VII -IX) gave the same compound: 1,3-dimethyl-trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-uric acid (X). The structures of these products were confirmed by U.V., I.R. and N.M.R. spectroscopy.
J Zajaczkowska
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Il Farmaco; edizione scientifica     Volume:  30     ISSN:  0430-0920     ISO Abbreviation:  Farmaco Sci     Publication Date:  1975 Nov 
Date Detail:
Created Date:  1976-02-21     Completed Date:  1976-02-21     Revised Date:  2009-06-05    
Medline Journal Info:
Nlm Unique ID:  0370716     Medline TA:  Farmaco Sci     Country:  ITALY    
Other Details:
Languages:  eng     Pagination:  927-34     Citation Subset:  IM    
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MeSH Terms
Indicators and Reagents
Magnetic Resonance Spectroscopy
Spectrophotometry, Ultraviolet
Theophylline* / analogs & derivatives
Xanthines / chemical synthesis*
Reg. No./Substance:
0/Cyclohexanes; 0/Indicators and Reagents; 0/Xanthines; 58-55-9/Theophylline

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