| The search for new drugs in the group of xanthine derivatives. XXXIX - Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines. | |
| | |
MedLine Citation:
|
PMID: 1193233 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
|
Reaction of 1,2-epoxycyclohexane with theophylline and 8-halotheophyllines in n-butanol n-propanol DMF medium brought up a good yield of the corresponding trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-derivatives (I - III). The products (VII - IX), (XII), (XIII) were formed by nucleophilic displacement of the halogen of (II) or (III) by alkoxides or cyclamines. Acid hydrolysis of the alkoxy derivatives (VII -IX) gave the same compound: 1,3-dimethyl-trans-diequatorial-DL-7-(2'-hydroxycyclohexyl-1')-uric acid (X). The structures of these products were confirmed by U.V., I.R. and N.M.R. spectroscopy. |
| | |
Authors:
|
J Zajaczkowska |
Related Documents
:
|
8330323 - Metabolism and cytotoxicity of trans,trans-muconaldehyde and its derivatives: potential... 18271033 - In vitro phototoxic potential and photochemical properties of imidazopyridine derivativ... 14586103 - Purification and identification of antimicrobial sesquiterpene lactones from yacon (sma... |
Publication Detail:
|
Type: Journal Article |
Journal Detail:
|
Title: Il Farmaco; edizione scientifica Volume: 30 ISSN: 0430-0920 ISO Abbreviation: Farmaco Sci Publication Date: 1975 Nov |
Date Detail:
|
Created Date: 1976-02-21 Completed Date: 1976-02-21 Revised Date: 2009-06-05 |
Medline Journal Info:
|
Nlm Unique ID: 0370716 Medline TA: Farmaco Sci Country: ITALY |
Other Details:
|
Languages: eng Pagination: 927-34 Citation Subset: IM |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
Cyclohexanes* Hydrolysis Indicators and Reagents Magnetic Resonance Spectroscopy Spectrophotometry, Ultraviolet Theophylline* / analogs & derivatives Xanthines / chemical synthesis* |
| Chemical | |
Reg. No./Substance:
|
0/Cyclohexanes; 0/Indicators and Reagents; 0/Xanthines; 58-55-9/Theophylline |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: Research on nitrogen heterocyclic compounds. IX. Synthesis of 5-hydroxy-2,4-dicarbethoxypyrroles
Next Document: Somatic cell genetic analysis of the interferon system.