Document Detail


The search for ideal antidote treatment in Gramoxone intoxication.
MedLine Citation:
PMID:  3106134     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The herbicide Gramoxone (the active ingredient is paraquat) actively accumulates in the lung in the mammalian organism, where it exerts its toxic effect through the generation of oxygen radicals. Efforts were made to counteract the toxic effect in experiments in mice. Its penetration into the cells was blocked with the diamines putrescine and cadaverine. The synthesis of the prostaglandins, which are supposed by responsible for the acute symptoms, was inhibited with Aspisol. Accumulation inhibition with biogenic amines is considered the most effective.
Authors:
K Barabás; L Szabó; B Matkovics
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  General pharmacology     Volume:  18     ISSN:  0306-3623     ISO Abbreviation:  Gen. Pharmacol.     Publication Date:  1987  
Date Detail:
Created Date:  1987-06-15     Completed Date:  1987-06-15     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  7602417     Medline TA:  Gen Pharmacol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  129-32     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antidotes / pharmacology*
Aspirin / analogs & derivatives,  pharmacology
Cadaverine / pharmacology
Kidney / metabolism
Lung / metabolism
Lysine / analogs & derivatives,  pharmacology
Male
Mice
Paraquat / antagonists & inhibitors,  metabolism,  poisoning*
Prostaglandin Antagonists / pharmacology
Prostaglandins / biosynthesis
Putrescine / pharmacology
Superoxide Dismutase / metabolism
Chemical
Reg. No./Substance:
0/Antidotes; 0/Prostaglandin Antagonists; 0/Prostaglandins; 110-60-1/Putrescine; 37933-78-1/acetylsalicylic acid lysinate; 462-94-2/Cadaverine; 4685-14-7/Paraquat; 50-78-2/Aspirin; 56-87-1/Lysine; EC 1.15.1.1/Superoxide Dismutase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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