Document Detail

A scintigraphical qualitative analysis of peripheral vascular sympathetic function with meta-[123I]iodobenzylguanidine in neurological patients with autonomic failure.
MedLine Citation:
PMID:  7560760     Owner:  NLM     Status:  MEDLINE    
In order to assess qualitatively the sympathetic functions of the peripheral vessels, we performed a scintigraphical study of the entire body with meta-[123I]iodobenzylguanidine (MIBG) in 13 patients with autonomic failure and 11 healthy subjects as control. The patients comprised seven with multiple system atrophy (MSA), two with pure autonomic failure (PAF), three with Parkinson's disease with autonomic failure (PD with AF) and one with familial amyloid polyneuropathy (FAP). No clinical evidence of vascular disease was noted in any of the patients and the control subjects. We investigated their autonomic functions using the head up tilt test as well as norepinephrine and isoproterenol infusion tests. We found that: (i) All of the control subjects showed satisfactory MIBG uptake; (ii) all of the patients with PAF and FAP, most of whom had postganglionic sympathetic lesions, showed supersensitivity and low MIBG uptake; (iii) almost all the patients with MSA, who were considered to have mainly preganglionic sympathetic lesions, showed supersensitivity and diminished MIBG uptake, although the patients with olivopontocerebellar atrophy showed supersensitivity but not diminished MIBG uptake. In conclusion, these results suggest that peripheral vascular scintigraphy using MIBG is useful in detecting peripheral adrenergic dysfunction.
M Hirayama; S Hakusui; Y Koike; K Ito; T Kato; M Ikeda; Y Hasegawa; A Takahashi
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of the autonomic nervous system     Volume:  53     ISSN:  0165-1838     ISO Abbreviation:  J. Auton. Nerv. Syst.     Publication Date:  1995 Jun 
Date Detail:
Created Date:  1995-11-20     Completed Date:  1995-11-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  8003419     Medline TA:  J Auton Nerv Syst     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  230-4     Citation Subset:  IM; S    
Department of Neurology, Nagoya University School of Medicine, Japan.
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MeSH Terms
Autonomic Nervous System Diseases / diagnosis,  physiopathology,  radionuclide imaging*
Iodine Radioisotopes / diagnostic use
Iodobenzenes / diagnostic use*
Isoproterenol / diagnostic use
Middle Aged
Norepinephrine / diagnostic use
Parkinson Disease / physiopathology,  radionuclide imaging
Regional Blood Flow / physiology
Sympathetic Nervous System / physiopathology,  radionuclide imaging*
Sympatholytics / diagnostic use*
Sympathomimetics / diagnostic use
Reg. No./Substance:
0/Iodine Radioisotopes; 0/Iodobenzenes; 0/Sympatholytics; 0/Sympathomimetics; 51-41-2/Norepinephrine; 7683-59-2/Isoproterenol; 77679-27-7/3-Iodobenzylguanidine

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