Document Detail


The schizophrenia brain exhibits low-level aneuploidy involving chromosome 1.
MedLine Citation:
PMID:  17889509     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Genetic instability manifested as loss or gain of whole chromosomes (aneuploidy) is a newly described feature of the human brain. Aneuploidy in the brain was hypothesized to be involved in schizophrenia pathogenesis. To gain further insights into the relationship between aneuploidy in the brain and schizophrenia pathogenesis, a molecular-cytogenetic study of chromosome 1 aneuploidy was performed. METHODS: Interphase multiprobe fluorescence in situ hybridization (FISH) with quantitative FISH (QFISH) and interphase chromosome-specific multicolor banding (ICS-MCB) were used to define aneuploidy rate in 12 unaffected and 12 schizophrenia brains. RESULTS: In the unaffected brain (n=12; 22,794 cells analyzed), average frequencies of stochastic chromosome 1 loss and gain were 0.3% (95%CI 0.2-0.4%) and 0.3% (95%CI 0.2-0.4%), respectively. The threshold level for stochastic chromosome gain and loss (the mean+3SD) in the normal brain was 0.7%. Average rate of aneuploidy in the schizophrenia brain (n=12; 28,482 cells analyzed) was 0.9% (95%CI 0.3-1.5%) for chromosome 1 loss and 0.9% (95%CI 0.2-1.7%) for chromosome 1 gain. Significantly increased level of mosaic aneuploidy involving chromosome 1 was revealed in two schizophrenia brains (3.6% and 4.7% of cells with chromosome 1 loss and gain, respectively). Stochastic aneuploidy rate for chromosome 1 in the schizophrenia brain without two outliers (n=10) reached 0.6% (95%CI 0.3-0.9%) for loss and 0.5% (0.2-0.9%) for gain and was higher than in controls (P=0.005 and P=0.001, respectively). CONCLUSIONS: Our findings support the hypothesis suggesting that subtle genomic imbalances manifesting as low-level mosaic aneuploidy may contribute to schizophrenia pathogenesis.
Authors:
Yuri B Yurov; Ivan Y Iourov; Svetlana G Vorsanova; Irina A Demidova; Viktor S Kravetz; Alphia K Beresheva; Alexei D Kolotii; Viktor V Monakchov; Natalia A Uranova; Viktor M Vostrikov; Ilia V Soloviev; Thomas Liehr
Related Documents :
8074169 - Search for a schizophrenia susceptibility locus on human chromosome 22.
21593209 - Reduced mad2 expression keeps relaxed kinetochores from arresting budding yeast in mito...
15898969 - Bipolar affective disorder in a male with a deletion of y chromosome -- a case report.
10767329 - Genome-wide scan for schizophrenia in the finnish population: evidence for a locus on c...
22133909 - Computerized cell-scanning system for evaluating human spermatogenesis in non-obstructi...
15578609 - Fine mapping of a region on chromosome 8p gives evidence for a qtl contributing to indi...
3301839 - Inaccessibility of tryptophan residues of recombinant human renin to quenching agents.
7587589 - Fish analysis of the telomere sequences of bulldog ants (myrmecia: formicidae).
16998229 - Comparative genotoxicity of the herbicides roundup, stomp and reglone in plant and mamm...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't     Date:  2007-09-21
Journal Detail:
Title:  Schizophrenia research     Volume:  98     ISSN:  0920-9964     ISO Abbreviation:  Schizophr. Res.     Publication Date:  2008 Jan 
Date Detail:
Created Date:  2007-12-17     Completed Date:  2008-03-31     Revised Date:  2010-09-02    
Medline Journal Info:
Nlm Unique ID:  8804207     Medline TA:  Schizophr Res     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  139-47     Citation Subset:  IM    
Affiliation:
National Research Center of Mental Health, Russian Academy of Medical Sciences, Moscow 119152, Russian Federation. y_yurov@yahoo.com
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Age of Onset
Aneuploidy*
Brain / metabolism*
Chromosomes, Human, Pair 1 / genetics*,  metabolism
Control Groups
Female
Genomic Instability / genetics
Humans
In Situ Hybridization, Fluorescence / methods
Male
Middle Aged
Mosaicism*
Schizophrenia / genetics*,  metabolism*
Stochastic Processes

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Gastrin transactivates the chromogranin A gene through MEK-1/ERK- and PKC-dependent phosphorylation ...
Next Document:  Learning-related changes in brain activity following errors and performance feedback in schizophreni...