Document Detail

The scarless heart.
MedLine Citation:
PMID:  12324214     Owner:  NLM     Status:  MEDLINE    
Over the past several years many mechanisms by which myocardial replacement could be achieved have been described. These include resident cardiac stem cells or circulating stem cells that can either differentiate into, or fuse to cardiomyocytes, or mature cells that can transdifferentiate into cardiomyocytes. However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacement. One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after injury. Results obtained with this model will be discussed.
John M Leferovich; Ellen Heber-Katz
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  13     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-26     Completed Date:  2003-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
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MeSH Terms
Cicatrix / pathology*
Heart / physiology*
Models, Animal
Myocardium / pathology*
Regeneration / physiology*
Wound Healing / physiology

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