Document Detail

The scarless heart.
MedLine Citation:
PMID:  12324214     Owner:  NLM     Status:  MEDLINE    
Over the past several years many mechanisms by which myocardial replacement could be achieved have been described. These include resident cardiac stem cells or circulating stem cells that can either differentiate into, or fuse to cardiomyocytes, or mature cells that can transdifferentiate into cardiomyocytes. However, the fact remains that after injury to the heart, the overriding response is scar formation with little myocardial replacement. One exception to this response is the MRL mouse, which heals with little scarring and shows nearly full myocardial replacement after injury. Results obtained with this model will be discussed.
John M Leferovich; Ellen Heber-Katz
Related Documents :
1031664 - Ultrastructural and physiological changes induced by atractylate in the canine myocardium.
19376124 - Hyperbaric oxygenation enhances transplanted cell graft and functional recovery in the ...
20350704 - Effects of adipose tissue-derived stem cell therapy after myocardial infarction: impact...
15385154 - Cellular recruitment and the development of the myocardium.
21185504 - High-resolution magnetic resonance myocardial perfusion imaging at 3.0-tesla to detect ...
2758684 - The quantitation of human ventricular myosin light chain 1 in serum after myocardial ne...
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, P.H.S.; Review    
Journal Detail:
Title:  Seminars in cell & developmental biology     Volume:  13     ISSN:  1084-9521     ISO Abbreviation:  Semin. Cell Dev. Biol.     Publication Date:  2002 Oct 
Date Detail:
Created Date:  2002-09-26     Completed Date:  2003-03-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9607332     Medline TA:  Semin Cell Dev Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  327-33     Citation Subset:  IM    
The Wistar Institute, 3601 Spruce Street, Philadelphia, PA 19104, USA.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Cicatrix / pathology*
Heart / physiology*
Models, Animal
Myocardium / pathology*
Regeneration / physiology*
Wound Healing / physiology

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Expert opinions of strategies for milk fever control.
Next Document:  Inducing cellular dedifferentiation: a potential method for enhancing endogenous regeneration in mam...