| Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering. | |
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MedLine Citation:
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PMID: 18723417 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Poly(lactide-co-glycotide) (PLGA) microspheres integrated into gelatin/chitosan/hyaluronan scaffolds were fabricated by freeze-drying and crosslinking with 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide. The effects of the microspheres on porosity, density, compressive modulus, phosphate-buffered saline uptake ratio and weight loss of the scaffolds were evaluated. Generally, a scaffold with a higher PLGA content had a lower porosity and weight loss, and a medium uptake ratio, but a larger apparent density and compressive modulus. When the PLGA content was lower than 50%, the PLGA-integrated scaffolds had a similar pore size (approximately 200microm) as that of the control, and as much as 90% of their porosity could be preserved. In vitro chondrocyte culture in the 50% PLGA-integrated scaffold demonstrated that the cells could proliferate and secrete extracellular matrix at the same level as in the control gelatin/chitosan/hyaluronan scaffold. |
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Authors:
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Huaping Tan; Jindan Wu; Lihong Lao; Changyou Gao |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2008-08-06 |
Journal Detail:
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Title: Acta biomaterialia Volume: 5 ISSN: 1878-7568 ISO Abbreviation: - Publication Date: 2009 Jan |
Date Detail:
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Created Date: 2008-11-26 Completed Date: 2009-03-30 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101233144 Medline TA: Acta Biomater Country: England |
Other Details:
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Languages: eng Pagination: 328-37 Citation Subset: IM |
Affiliation:
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Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, and Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Biocompatible Materials / chemistry* Cartilage / metabolism* Cell Proliferation Chitosan / administration & dosage* Chondrocytes / metabolism Compressive Strength Gelatin / administration & dosage* Hyaluronic Acid / administration & dosage* Lactic Acid / chemistry* Microspheres Models, Biological Polyglycolic Acid / chemistry* Porosity Rabbits Tissue Engineering / methods* |
| Chemical | |
Reg. No./Substance:
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0/Biocompatible Materials; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 9000-70-8/Gelatin; 9004-61-9/Hyaluronic Acid; 9012-76-4/Chitosan |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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