Document Detail


Gelatin/chitosan/hyaluronan scaffold integrated with PLGA microspheres for cartilage tissue engineering.
MedLine Citation:
PMID:  18723417     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Poly(lactide-co-glycotide) (PLGA) microspheres integrated into gelatin/chitosan/hyaluronan scaffolds were fabricated by freeze-drying and crosslinking with 1-ethyl-3-(3-dimethyl aminopropyl)carbodiimide. The effects of the microspheres on porosity, density, compressive modulus, phosphate-buffered saline uptake ratio and weight loss of the scaffolds were evaluated. Generally, a scaffold with a higher PLGA content had a lower porosity and weight loss, and a medium uptake ratio, but a larger apparent density and compressive modulus. When the PLGA content was lower than 50%, the PLGA-integrated scaffolds had a similar pore size (approximately 200microm) as that of the control, and as much as 90% of their porosity could be preserved. In vitro chondrocyte culture in the 50% PLGA-integrated scaffold demonstrated that the cells could proliferate and secrete extracellular matrix at the same level as in the control gelatin/chitosan/hyaluronan scaffold.
Authors:
Huaping Tan; Jindan Wu; Lihong Lao; Changyou Gao
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-08-06
Journal Detail:
Title:  Acta biomaterialia     Volume:  5     ISSN:  1878-7568     ISO Abbreviation:  -     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2008-11-26     Completed Date:  2009-03-30     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101233144     Medline TA:  Acta Biomater     Country:  England    
Other Details:
Languages:  eng     Pagination:  328-37     Citation Subset:  IM    
Affiliation:
Key Laboratory of Macromolecular Synthesis and Functionalization, Ministry of Education, and Department of Polymer Science and Engineering, Zhejiang University, Hangzhou 310027, China.
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MeSH Terms
Descriptor/Qualifier:
Animals
Biocompatible Materials / chemistry*
Cartilage / metabolism*
Cell Proliferation
Chitosan / administration & dosage*
Chondrocytes / metabolism
Compressive Strength
Gelatin / administration & dosage*
Hyaluronic Acid / administration & dosage*
Lactic Acid / chemistry*
Microspheres
Models, Biological
Polyglycolic Acid / chemistry*
Porosity
Rabbits
Tissue Engineering / methods*
Chemical
Reg. No./Substance:
0/Biocompatible Materials; 0/polylactic acid-polyglycolic acid copolymer; 26009-03-0/Polyglycolic Acid; 50-21-5/Lactic Acid; 9000-70-8/Gelatin; 9004-61-9/Hyaluronic Acid; 9012-76-4/Chitosan

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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