| The safety and tolerability of GLP-1 receptor agonists in the treatment of type-2 diabetes. | |
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MedLine Citation:
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PMID: 20716148 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Established therapies for type-2 diabetes effectively reduce blood glucose, but are often associated with adverse effects that pose risks to patient's health or diminish adherence to treatment. Weight gain, hypoglycaemia and gastrointestinal symptoms are commonly reported and some agents may not be safe for use in patients with renal impairment or elevated cardiovascular risk. New treatments based on the action of the endogenous human hormone glucagon-like peptide-1 (GLP-1), including exenatide and liraglutide, are available. These therapies provide a novel pharmacological approach to glycaemic control via multiple mechanisms of action, and accordingly exhibit different safety and tolerability profiles than conventional treatments. GLP-1 receptor agonists stimulate insulin release only in the presence of elevated blood glucose and are therefore associated with a fairly low risk of hypoglycaemia. Gastrointestinal symptoms are common but transient, and there appears to be little potential for interaction with other drugs. GLP-1 receptor agonists are associated with weight loss rather than weight gain. As protein-based therapies, these agents have the potential to induce antibody formation, but the impact on efficacy and safety is minor. GLP-1 receptor agonists thus offer a new and potentially useful option for clinicians concerned about some of the common adverse effects of type-2 diabetes therapies. |
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Authors:
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D Russell-Jones |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of clinical practice Volume: 64 ISSN: 1742-1241 ISO Abbreviation: Int. J. Clin. Pract. Publication Date: 2010 Sep |
Date Detail:
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Created Date: 2010-08-18 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 9712381 Medline TA: Int J Clin Pract Country: England |
Other Details:
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Languages: eng Pagination: 1402-14 Citation Subset: IM |
Affiliation:
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Department of Diabetes and Endocrinology, Cedar Centre at the Royal Surrey County Hospital, Guildford, UK. D.Russell-Jones@surrey.ac.uk |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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