| The safety of protamine sulfate in diabetics undergoing cardiac catheterization. | |
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MedLine Citation:
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PMID: 3349513 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The frequency of anaphylactoid reactions to protamine sulfate was examined by reviewing the records of diabetic patients undergoing cardiac catheterization over a 5-year period, and by prospectively monitoring diabetic patients receiving NPH insulin during the infusion of protamine sulfate. No anaphylactoid reactions were noted after protamine administration (48 +/- 5 mg) in the retrospective study in either patients with prior exposure to protamine (74 catheterizations) or in diabetics with no exposure to protamine (132 catheterizations). In the prospective study, no anaphylactoid reactions were seen in the 24 NPH insulin-dependent diabetics during the infusion of protamine sulfate (45 +/- 5 mg). Five of the 42 patients (12%) from the retrospective study who underwent vascular surgery developed severe reactions to much larger doses of protamine (380 +/- 118 mg). Diabetics with prior exposure to protamine sulfate do not appear to be at increased risk of anaphylactoid reaction after the administration of protamine sulfate in the dose range of less than 50 mg at the time of cardiac catheterization. |
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Authors:
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D C Reed; J A Gascho |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Catheterization and cardiovascular diagnosis Volume: 14 ISSN: 0098-6569 ISO Abbreviation: Cathet Cardiovasc Diagn Publication Date: 1988 |
Date Detail:
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Created Date: 1988-04-22 Completed Date: 1988-04-22 Revised Date: 2008-11-21 |
Medline Journal Info:
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Nlm Unique ID: 7508512 Medline TA: Cathet Cardiovasc Diagn Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 19-23 Citation Subset: IM |
Affiliation:
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University of Virginia School of Medicine, Charlottesville. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Anaphylaxis
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chemically induced* Diabetes Mellitus* Female Heart Catheterization* Humans Insulin, NPH* Male Middle Aged Prospective Studies Protamines / diagnostic use, toxicity* Retrospective Studies Risk Factors |
| Chemical | |
Reg. No./Substance:
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0/Protamines; 53027-39-7/Insulin, NPH |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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