Document Detail

The safety of low-potassium dialysis.
MedLine Citation:
PMID:  21166879     Owner:  NLM     Status:  MEDLINE    
Patients with kidney failure depend on dialysis to maintain neutral potassium balance. The amount of potassium removed during a hemodialysis treatment is inversely proportional to the potassium concentration in the dialysis bath. Nephrologists adjust the dialysis bath potassium to account for individual variation in potassium intake among their patients. This management strategy is remarkably successful, because most patients on maintenance hemodialysis have a normal predialysis serum potassium concentration. But the serum potassium concentration of patients on maintenance hemodialysis is not constant over time; it follows a sawtooth pattern. It is this instability--especially the acute fall during dialysis--that has concerned nephrologists for decades, particularly in view of the crucial role of potassium in cardiac electrophysiology. This concern is amplified by the extraordinarily high rate of sudden death among patients on maintenance hemodialysis. In this paper, we review the safety of low-potassium dialysis and make recommendations for managing patients whose serum potassium concentration falls outside the target range.
Lawrence S Weisberg; Jean-Sebastien Rachoin
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Publication Detail:
Type:  Journal Article; Review     Date:  2010-12-20
Journal Detail:
Title:  Seminars in dialysis     Volume:  23     ISSN:  1525-139X     ISO Abbreviation:  Semin Dial     Publication Date:    2010 Nov-Dec
Date Detail:
Created Date:  2010-12-23     Completed Date:  2011-05-17     Revised Date:  2011-06-13    
Medline Journal Info:
Nlm Unique ID:  8911629     Medline TA:  Semin Dial     Country:  United States    
Other Details:
Languages:  eng     Pagination:  556-60     Citation Subset:  IM    
Copyright Information:
© 2010 Wiley Periodicals, Inc.
Division of Nephrology, UMDNJ-Robert Wood Johnson Medical School, Cooper University Hospital, Camden, New Jersey 08103, USA.
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MeSH Terms
Dialysis Solutions / pharmacokinetics*
Dose-Response Relationship, Drug
Kidney Failure, Chronic / blood,  therapy*
Potassium / pharmacokinetics*
Renal Dialysis / methods*
Reg. No./Substance:
0/Dialysis Solutions; 7440-09-7/Potassium

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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