| The safety of intravenous dipyridamole thallium myocardial perfusion imaging. Intravenous Dipyridamole Thallium Imaging Study Group. | |
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MedLine Citation:
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PMID: 2107985 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Clinical data on 3,911 patients were collected from 64 individual investigators to evaluate the safety of intravenous dipyridamole-thallium imaging as an alternative to exercise thallium imaging for the evaluation of coronary artery disease. There were two deaths because of myocardial infarctions, two nonfatal myocardial infarctions, and six cases of acute bronchospasm. Chest pain occurred in 770 patients (19.7%). Headache and dizziness were reported by 476 patients (12.2%) and 460 patients (11.8%), respectively. ST-T changes on the electrocardiogram were seen in 292 patients (7.5%). Use of parenteral aminophylline to treat adverse events associated with intravenous dipyridamole brought complete relief of symptoms in 439 of 454 patients (96.7%). There is a potential for increased risk for serious ischemic events in patients with a history of unstable angina who are administered intravenous dipyridamole. In patients with acutely unstable angina (i.e., continuing chest pain) or in the acute phase of myocardial infarction, use of intravenous dipyridamole in thallium scintigraphy should be avoided. There is also an increased risk for bronchospasm in patients with a history of asthma; acute bronchospasm can be relieved immediately by administration of aminophylline. These results demonstrate that intravenous dipyridamole-thallium scintigraphy is a relatively safe, noninvasive technique for the evaluation of coronary artery disease. |
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Authors:
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A Ranhosky; J Kempthorne-Rawson |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Circulation Volume: 81 ISSN: 0009-7322 ISO Abbreviation: Circulation Publication Date: 1990 Apr |
Date Detail:
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Created Date: 1990-05-02 Completed Date: 1990-05-02 Revised Date: 2007-11-15 |
Medline Journal Info:
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Nlm Unique ID: 0147763 Medline TA: Circulation Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 1205-9 Citation Subset: AIM; IM |
Affiliation:
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Department of Clinical Research, Boehringer Ingelheim Pharmaceuticals, Inc, Ridgefield, CT 06877. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Aged Aminophylline / therapeutic use Bronchial Spasm / chemically induced, drug therapy Chest Pain / chemically induced, drug therapy Dipyridamole / adverse effects*, diagnostic use Female Headache / chemically induced Heart / radionuclide imaging* Hemodynamics / drug effects Humans Injections, Intravenous Male Middle Aged Myocardial Infarction / chemically induced Nausea / chemically induced Nitroglycerin / therapeutic use Perfusion Thallium / diagnostic use* |
| Chemical | |
Reg. No./Substance:
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317-34-0/Aminophylline; 55-63-0/Nitroglycerin; 58-32-2/Dipyridamole; 7440-28-0/Thallium |
| Comments/Corrections | |
Comment In:
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Circulation. 1990 Apr;81(4):1425-7
[PMID:
2317920
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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