Document Detail

The safety and efficacy of ibutilide in children and in patients with congenital heart disease.
MedLine Citation:
PMID:  17669084     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: The safety and efficacy of ibutilide in the cardioversion of atrial flutter and atrial fibrillation in children and in patients with congenital heart disease (CHD) is unknown. METHODS: Data from 19 patients (age 6 months to 34 years, median 16 years) who received ibutilide for atrial flutter or atrial fibrillation between 1996 and 2005 was retrospectively reviewed. There were 15 patients with CHD (14 had prior heart surgery); four children had normal heart structure. RESULTS: There were 74 episodes of atrial flutter and four episodes of atrial fibrillation (median episodes per patient was one, range 1-31). Ibutilide converted 55 of all the episodes (71%). Ibutilide was successful during its first-ever administration in 12 of 19 patients (63%). Fourteen episodes in six patients required electrical cardioversion after ibutilide failed. There were no episodes of symptomatic bradycardia. One patient went into torsade de pointes and one patient had nonsustained ventricular tachycardia. CONCLUSION: With careful monitoring, ibutilide can be an effective tool in selected patients for cardioversion of atrial flutter.
Andrew W Hoyer; Seshadri Balaji
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Pacing and clinical electrophysiology : PACE     Volume:  30     ISSN:  0147-8389     ISO Abbreviation:  Pacing Clin Electrophysiol     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-08-02     Completed Date:  2007-11-20     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7803944     Medline TA:  Pacing Clin Electrophysiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1003-8     Citation Subset:  IM    
Department of Pediatrics, Division of Pediatric Cardiology, Oregon Health & Science University, Portland, OR 97239, USA.
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MeSH Terms
Anti-Arrhythmia Agents / therapeutic use*
Atrial Fibrillation / drug therapy*
Atrial Flutter / drug therapy*
Child, Preschool
Heart Defects, Congenital / drug therapy*
Pacemaker, Artificial
Sulfonamides / therapeutic use*
Treatment Outcome
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Sulfonamides; 130350-52-6/ibutilide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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