Document Detail

The safety and efficacy of clozapine in severe treatment-resistant schizophrenic patients in the UK. Clozapine Study Group.
MedLine Citation:
PMID:  8075904     Owner:  NLM     Status:  MEDLINE    
In order to assess the safety and some efficacy aspects of clozapine under UK conditions, 54 in-patients with severe treatment-resistant schizophrenic disorders were evaluated using several scales before and during treatment. Of the 54 evaluated, 26 completed the 26-week study. Of these patients, 20 showed improvement in psychopathology, often to a marked degree, involving both positive and negative symptoms. Some oral-facial extrapyramidal side-effects decreased as well. Two patients developed neutropenia, but recovered on discontinuation of clozapine. The most frequent adverse event was hypersalivation, and five patients suffered from seizures. It is concluded that clozapine is worth considering for the treatment of severe treatment-resistant patients in the UK.
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Publication Detail:
Type:  Clinical Trial; Journal Article; Multicenter Study    
Journal Detail:
Title:  The British journal of psychiatry : the journal of mental science     Volume:  163     ISSN:  0007-1250     ISO Abbreviation:  Br J Psychiatry     Publication Date:  1993 Aug 
Date Detail:
Created Date:  1994-10-04     Completed Date:  1994-10-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  0342367     Medline TA:  Br J Psychiatry     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  150-4     Citation Subset:  IM    
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MeSH Terms
Chronic Disease
Clozapine / adverse effects,  pharmacology,  therapeutic use*
Drug Resistance
Dyskinesia, Drug-Induced
Great Britain
Middle Aged
Schizophrenia / drug therapy*
Schizophrenic Psychology*
Treatment Outcome
Reg. No./Substance:

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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