| The safety and efficacy of clozapine in severe treatment-resistant schizophrenic patients in the UK. Clozapine Study Group. | |
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MedLine Citation:
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PMID: 8075904 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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In order to assess the safety and some efficacy aspects of clozapine under UK conditions, 54 in-patients with severe treatment-resistant schizophrenic disorders were evaluated using several scales before and during treatment. Of the 54 evaluated, 26 completed the 26-week study. Of these patients, 20 showed improvement in psychopathology, often to a marked degree, involving both positive and negative symptoms. Some oral-facial extrapyramidal side-effects decreased as well. Two patients developed neutropenia, but recovered on discontinuation of clozapine. The most frequent adverse event was hypersalivation, and five patients suffered from seizures. It is concluded that clozapine is worth considering for the treatment of severe treatment-resistant patients in the UK. |
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Authors:
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Publication Detail:
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Type: Clinical Trial; Journal Article; Multicenter Study |
Journal Detail:
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Title: The British journal of psychiatry : the journal of mental science Volume: 163 ISSN: 0007-1250 ISO Abbreviation: Br J Psychiatry Publication Date: 1993 Aug |
Date Detail:
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Created Date: 1994-10-04 Completed Date: 1994-10-04 Revised Date: 2004-11-17 |
Medline Journal Info:
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Nlm Unique ID: 0342367 Medline TA: Br J Psychiatry Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 150-4 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Adult Chronic Disease Clozapine / adverse effects, pharmacology, therapeutic use* Drug Resistance Dyskinesia, Drug-Induced Female Great Britain Humans Male Middle Aged Neutropenia Schizophrenia / drug therapy* Schizophrenic Psychology* Sialorrhea Treatment Outcome |
| Chemical | |
Reg. No./Substance:
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5786-21-0/Clozapine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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