Document Detail

The safety of conception occurring shortly after methotrexate treatment of an ectopic pregnancy.
MedLine Citation:
PMID:  19103279     Owner:  NLM     Status:  MEDLINE    
The objective of this study was to determine whether a single or repeated injection of methotrexate (MTX) to treat ectopic pregnancy results in either teratogenicity or other bad obstetric outcome in the pregnancy that shortly follows treatment. Data were retrieved from the medical records of 314 women treated with MTX for ectopic pregnancy in our institute (2000-2006) included age, MTX dosage, interval between last MTX treatment to conception, results of ultrasonographic follow-up of the subsequent pregnancy, triple test, karyotype testing, pregnancy outcome, and newborn weight and Apgar score. A logistic regression model based on pregnancy outcome as the dependent variable and interval since last MTX treatment as the independent variable estimated the odds ratio for the safety of conception occurring shortly after the treatment. Complete information was obtained for 125 pregnancies. Forty-five pregnancies occurred within 6 months (mean 3.6+/-1.7) after the last MTX treatment. The outcome of these pregnancies was compared with that of 80 pregnancies which occurred > or =6 months (mean 23.6+/-14.7) after the last MTX treatment. The fetal malformation and adverse outcome rates for both groups were similar (odds ratio 1.003, 95% CI 0.98-1.02). According to a logistic regression analysis, the interval between the last MTX treatment for ectopic pregnancy had no effect on the outcome of the pregnancy that shortly followed it. The results of this study support the notion that conceiving within the first 6 months after treatment with MTX for ectopic pregnancy is safe and not associated with any increase in the examined adverse pregnancy outcome parameters.
Ran Svirsky; Uri Rozovski; Zvi Vaknin; Moty Pansky; David Schneider; Reuvit Halperin
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Publication Detail:
Type:  Journal Article     Date:  2008-12-03
Journal Detail:
Title:  Reproductive toxicology (Elmsford, N.Y.)     Volume:  27     ISSN:  0890-6238     ISO Abbreviation:  Reprod. Toxicol.     Publication Date:  2009 Jan 
Date Detail:
Created Date:  2009-02-02     Completed Date:  2009-04-01     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8803591     Medline TA:  Reprod Toxicol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  85-7     Citation Subset:  IM    
Department of Obstetrics and Gynecology, Assaf Harofe Medical Center, Zerifin 70300, Israel.
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MeSH Terms
Abortifacient Agents, Nonsteroidal / therapeutic use*
Congenital Abnormalities / epidemiology
Fertilization / drug effects*
Israel / epidemiology
Methotrexate / therapeutic use*
Odds Ratio
Pregnancy Outcome / epidemiology*
Pregnancy, Ectopic / drug therapy*
Time Factors
Reg. No./Substance:
0/Abortifacient Agents, Nonsteroidal; 59-05-2/Methotrexate

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