| The safety of antidepressant use in pregnancy. | |
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MedLine Citation:
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PMID: 15794719 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Depression during pregnancy affects an estimated 10 - 20% of women, some of whom will require treatment with antidepressants. It is of great importance that the safety of this particular class of drugs is reviewed, to ensure the optimal treatment of the mother while protecting her unborn child. In this review, current safety data on all available antidepressants are discussed in detail, including the pharmacokinetics of the maternal-fetal unit and the epidemiological studies that have been published to date. The classes of antidepressants discussed include: tricyclics, selective serotonin re-uptake inhibitors and other antidepressants. After reviewing these studies, it is evident that these drugs appear to be relatively safe to take during pregnancy. This evidence-based information will be helpful to women and their healthcare providers, when the decision of whether or not to treat with anti-depressants during pregnancy must be made. |
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Authors:
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Sanjog Kalra; Leslie Born; Moumita Sarkar; Adrienne Einarson |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Expert opinion on drug safety Volume: 4 ISSN: 1744-764X ISO Abbreviation: Expert Opin Drug Saf Publication Date: 2005 Mar |
Date Detail:
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Created Date: 2005-03-29 Completed Date: 2005-12-19 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101163027 Medline TA: Expert Opin Drug Saf Country: England |
Other Details:
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Languages: eng Pagination: 273-84 Citation Subset: IM |
Affiliation:
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The Hospital for Sick Children, The Motherisk Program, Division of Clinical Pharmacology & Toxicology, 555 University Avenue, Toronto, Ontario M5G 1X8, Canada. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Abortion, Induced Animals Antidepressive Agents / adverse effects*, pharmacokinetics Antidepressive Agents, Tricyclic / adverse effects Child Development / drug effects Depression / drug therapy* Female Humans Hypericum / adverse effects Infant, Newborn Infant, Newborn, Diseases / chemically induced* Maternal-Fetal Exchange Pregnancy Pregnancy Complications / drug therapy* Prenatal Exposure Delayed Effects* Serotonin Uptake Inhibitors / adverse effects Teratogens |
| Chemical | |
Reg. No./Substance:
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0/Antidepressive Agents; 0/Antidepressive Agents, Tricyclic; 0/Serotonin Uptake Inhibitors; 0/Teratogens |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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