Document Detail

The safety of flucloxacillin in HIV-infected patients with positive HLA-B*5701 genotype.
MedLine Citation:
PMID:  23032409     Owner:  NLM     Status:  MEDLINE    
Positive HLA-B*5701 genotype has recently been identified as the main genetic risk factor for flucloxacillin drug-induced liver injury (DILI). Testing for HLA-B*5701 is routine in many HIV clinics to identify those at risk of hypersensitivity reaction (HSR) to abacavir. Considering the high prevalence of soft-tissue infections in HIV patients, we conducted a retrospective study to investigate whether flucloxacillin use was associated with adverse events in HIV patients known to be HLA-B*5701 positive.
Jaime H Vera; Nadia Naous; Nicola Mackie; Alan Winston; Graham Cooke
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  27     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-10     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  484-5     Citation Subset:  IM; X    
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MeSH Terms
Anti-Bacterial Agents / administration & dosage,  adverse effects*
Anti-HIV Agents / therapeutic use
Drug Hypersensitivity / genetics,  immunology
Drug-Induced Liver Injury / etiology*,  genetics,  immunology
Floxacillin / administration & dosage,  adverse effects*
HIV Infections / drug therapy,  genetics,  immunology*
HLA-B Antigens / drug effects*,  genetics
Middle Aged
Retrospective Studies
Risk Factors
Grant Support
MR/K007688/1//Medical Research Council; //Wellcome Trust
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-HIV Agents; 0/HLA-B Antigens; 0/HLA-B*57:01 antigen; 43B2M34G2V/Floxacillin
Comment In:
AIDS. 2013 Jan 28;27(3):491-2   [PMID:  23291545 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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