Document Detail


The safety of flucloxacillin in HIV-infected patients with positive HLA-B*5701 genotype.
MedLine Citation:
PMID:  23032409     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Positive HLA-B*5701 genotype has recently been identified as the main genetic risk factor for flucloxacillin drug-induced liver injury (DILI). Testing for HLA-B*5701 is routine in many HIV clinics to identify those at risk of hypersensitivity reaction (HSR) to abacavir. Considering the high prevalence of soft-tissue infections in HIV patients, we conducted a retrospective study to investigate whether flucloxacillin use was associated with adverse events in HIV patients known to be HLA-B*5701 positive.
Authors:
Jaime H Vera; Nadia Naous; Nicola Mackie; Alan Winston; Graham Cooke
Related Documents :
2025859 - Intracerebral hodgkin's disease in a human immunodeficiency virus-seropositive patient.
25254559 - Men living with diagnosed hiv who have sex with men: progress along the continuum of hi...
25236189 - Routine cd4 cell count monitoring seldom contributes to clinical decision-making on ant...
7188959 - X-linked lymphoproliferative syndrome registry report.
24383469 - Physiotherapy rehabilitation in the context of hiv and disability in kwazulu-natal, sou...
25258129 - Vision: a regional performance improvement initiative for hiv health care providers.
22511909 - A case of emphysematous hepatitis with spontaneous pneumoperitoneum in a patient with h...
21305909 - Self-esteem and hiv risk practices among young adult ecstasy users.
8863369 - Invasive candida norvegensis infection in immunocompromised patients.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  AIDS (London, England)     Volume:  27     ISSN:  1473-5571     ISO Abbreviation:  AIDS     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2013-01-07     Completed Date:  2013-06-10     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  8710219     Medline TA:  AIDS     Country:  England    
Other Details:
Languages:  eng     Pagination:  484-5     Citation Subset:  IM; X    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Anti-Bacterial Agents / administration & dosage,  adverse effects*
Anti-HIV Agents / therapeutic use
Drug Hypersensitivity / genetics,  immunology
Drug-Induced Liver Injury / etiology*,  genetics,  immunology
Female
Floxacillin / administration & dosage,  adverse effects*
Genotype
HIV Infections / drug therapy,  genetics,  immunology*
HLA-B Antigens / drug effects*,  genetics
Humans
Male
Middle Aged
Retrospective Studies
Risk Factors
Grant Support
ID/Acronym/Agency:
MR/K007688/1//Medical Research Council; //Wellcome Trust
Chemical
Reg. No./Substance:
0/Anti-Bacterial Agents; 0/Anti-HIV Agents; 0/HLA-B Antigens; 0/HLA-B*57:01 antigen; 43B2M34G2V/Floxacillin
Comments/Corrections
Comment In:
AIDS. 2013 Jan 28;27(3):491-2   [PMID:  23291545 ]

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Unilateral lesion of the nigrostriatal pathway decreases the response of GABA interneurons in the do...
Next Document:  Marked Increase of the Astrocytic Marker S100B in the Cerebrospinal Fluid of HIV-infected Patients o...