| A safe strategy to decrease fetal lead exposure in a woman with chronic intoxication. | |
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MedLine Citation:
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PMID: 20459344 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development. The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established. We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We (a) advised her to delay conception until 'toxicological clearance', (b) treated her with multiple courses of lead chelator, DMSA, and (c) prescribed oral calcium. Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure. |
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Authors:
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Adi Leiba; Howard Hu; Amin Zheng; Stefanos N Kales |
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Publication Detail:
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Type: Case Reports; Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians Volume: 23 ISSN: 1476-4954 ISO Abbreviation: J. Matern. Fetal. Neonatal. Med. Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-16 Completed Date: 2010-11-04 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 101136916 Medline TA: J Matern Fetal Neonatal Med Country: England |
Other Details:
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Languages: eng Pagination: 932-4 Citation Subset: IM |
Affiliation:
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Department of Internal Medicine, Mount Auburn Hospital, Harvard Medical School, Cambridge, Massachusetts, USA. drleiba@gmail.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Calcium / therapeutic use Chelating Agents / therapeutic use* Female Fetal Diseases / prevention & control* Humans Lead Poisoning / drug therapy*, prevention & control Pregnancy Prenatal Exposure Delayed Effects / prevention & control* Succimer / therapeutic use* |
| Grant Support | |
ID/Acronym/Agency:
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R01-05257//PHS HHS; R01-07821//PHS HHS |
| Chemical | |
Reg. No./Substance:
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0/Chelating Agents; 304-55-2/Succimer; 7440-70-2/Calcium |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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