Document Detail


A safe strategy to decrease fetal lead exposure in a woman with chronic intoxication.
MedLine Citation:
PMID:  20459344     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
During pregnancy skeletal lead is mobilized by maternal bone turnover and can threaten fetal development. The exact strategy suggested to women of childbearing age, who were chronically exposed to lead, and, thus, have high bone lead burden, is not well established. We describe 4 years of follow-up of a 29-year-old woman with chronic lead intoxication. We (a) advised her to delay conception until 'toxicological clearance', (b) treated her with multiple courses of lead chelator, DMSA, and (c) prescribed oral calcium. Patient had low blood lead and protoporphyrin level during pregnancy until delivery. Delaying conception, lead chelation, and calcium supplementation can decrease fetal exposure.
Authors:
Adi Leiba; Howard Hu; Amin Zheng; Stefanos N Kales
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Publication Detail:
Type:  Case Reports; Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  The journal of maternal-fetal & neonatal medicine : the official journal of the European Association of Perinatal Medicine, the Federation of Asia and Oceania Perinatal Societies, the International Society of Perinatal Obstetricians     Volume:  23     ISSN:  1476-4954     ISO Abbreviation:  J. Matern. Fetal. Neonatal. Med.     Publication Date:  2010 Aug 
Date Detail:
Created Date:  2010-07-16     Completed Date:  2010-11-04     Revised Date:  2014-05-08    
Medline Journal Info:
Nlm Unique ID:  101136916     Medline TA:  J Matern Fetal Neonatal Med     Country:  England    
Other Details:
Languages:  eng     Pagination:  932-4     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Calcium / therapeutic use
Chelating Agents / therapeutic use*
Female
Fetal Diseases / prevention & control*
Humans
Lead Poisoning / drug therapy*,  prevention & control
Pregnancy
Prenatal Exposure Delayed Effects / prevention & control*
Succimer / therapeutic use*
Grant Support
ID/Acronym/Agency:
R01 ES005257/ES/NIEHS NIH HHS; R01-05257//PHS HHS; R01-07821//PHS HHS
Chemical
Reg. No./Substance:
0/Chelating Agents; DX1U2629QE/Succimer; SY7Q814VUP/Calcium
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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