| sIL-6R: more than an agonist? | |
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MedLine Citation:
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PMID: 17724457 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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On target cells, interleukin-6 (IL-6) interacts with its receptor complex consisting of the membrane-bound IL-6 receptor (IL-6R) and the signal transducing protein gp130. IL-6R can exist as a soluble protein (sIL-6R), which binds the ligand IL-6. This soluble complex can bind to gp130 on cells that lack the membrane-bound IL-6R and initiate signaling. This process is named transsignaling. The significance of transsignaling via sIL-6R is underlined by different publications and exceeds very probably the significance of the membrane-bound IL-6R. It is the general assumption that sIL-6R acts as an agonist in combination with IL-6 resulting in an enhancement of the IL-6 effects. In this article, we suppose 'non-agonistic' properties. There are several publications that give reasons to speculate that sIL-6R (a) has IL-6-antagonistic effects, (b) has orphan properties and (c) interacts with yet unknown binding partners different from IL-6. Knowledge about additional properties of sIL-6R will enlarge the biologic understanding of this molecule and might give an explanation for the sometimes contrasting effects of the cytokine IL-6. |
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Authors:
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Heike Knüpfer; Rainer Preiss |
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Publication Detail:
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Type: Journal Article; Review Date: 2007-08-28 |
Journal Detail:
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Title: Immunology and cell biology Volume: 86 ISSN: 0818-9641 ISO Abbreviation: Immunol. Cell Biol. Publication Date: 2008 Jan |
Date Detail:
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Created Date: 2008-01-03 Completed Date: 2008-09-15 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8706300 Medline TA: Immunol Cell Biol Country: Australia |
Other Details:
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Languages: eng Pagination: 87-91 Citation Subset: IM |
Affiliation:
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Institute of Clinical Pharmacology, University of Leipzig, Härtelstrasse 16-18, Leipzig, Germany. Heike.Knuepfer@medizin.uni-leipzig.de |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Apoptosis / immunology Cytokine Receptor gp130 / immunology, metabolism Humans Inflammation / immunology Interleukin-6 / antagonists & inhibitors, immunology, metabolism* Mice Protein Binding Rats Receptors, Interleukin-6 / agonists*, immunology, metabolism* Recombinant Fusion Proteins / antagonists & inhibitors, immunology, metabolism Signal Transduction / immunology* |
| Chemical | |
Reg. No./Substance:
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0/Interleukin-6; 0/Receptors, Interleukin-6; 0/Recombinant Fusion Proteins; 0/Sgp130Fc protein; 133483-10-0/Cytokine Receptor gp130 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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