| The s-layer glycome-adding to the sugar coat of bacteria. | |
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MedLine Citation:
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PMID: 20871840 Owner: NLM Status: PubMed-not-MEDLINE |
Abstract/OtherAbstract:
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The amazing repertoire of glycoconjugates present on bacterial cell surfaces includes lipopolysaccharides, capsular polysaccharides, lipooligosaccharides, exopolysaccharides, and glycoproteins. While the former are constituents of Gram-negative cells, we review here the cell surface S-layer glycoproteins of Gram-positive bacteria. S-layer glycoproteins have the unique feature of self-assembling into 2D lattices providing a display matrix for glycans with periodicity at the nanometer scale. Typically, bacterial S-layer glycans are O-glycosidically linked to serine, threonine, or tyrosine residues, and they rely on a much wider variety of constituents, glycosidic linkage types, and structures than their eukaryotic counterparts. As the S-layer glycome of several bacteria is unravelling, a picture of how S-layer glycoproteins are biosynthesized is evolving. X-ray crystallography experiments allowed first insights into the catalysis mechanism of selected enzymes. In the future, it will be exciting to fully exploit the S-layer glycome for glycoengineering purposes and to link it to the bacterial interactome. |
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Authors:
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Robin Ristl; Kerstin Steiner; Kristof Zarschler; Sonja Zayni; Paul Messner; Christina Schäffer |
Publication Detail:
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Type: Journal Article Date: 2010-08-10 |
Journal Detail:
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Title: International journal of microbiology Volume: 2011 ISSN: 1687-9198 ISO Abbreviation: Int J Microbiol Publication Date: 2011 |
Date Detail:
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Created Date: 2010-09-27 Completed Date: 2011-07-14 Revised Date: 2011-09-15 |
Medline Journal Info:
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Nlm Unique ID: 101516125 Medline TA: Int J Microbiol Country: Egypt |
Other Details:
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Languages: eng Pagination: - Citation Subset: - |
Affiliation:
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Department of NanoBiotechnology, Vienna Institute of BioTechnology, University of Natural Resources and Life Sciences, Muthgasse 11, 1190 Vienna, Austria. |
Export Citation:
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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P 19047-B12//Austrian Science Fund FWF; P 20605-B12//Austrian Science Fund FWF; P 20745-B11//Austrian Science Fund FWF; P 21954-B20//Austrian Science Fund FWF |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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