Document Detail


The s-layer glycome-adding to the sugar coat of bacteria.
MedLine Citation:
PMID:  20871840     Owner:  NLM     Status:  PubMed-not-MEDLINE    
Abstract/OtherAbstract:
The amazing repertoire of glycoconjugates present on bacterial cell surfaces includes lipopolysaccharides, capsular polysaccharides, lipooligosaccharides, exopolysaccharides, and glycoproteins. While the former are constituents of Gram-negative cells, we review here the cell surface S-layer glycoproteins of Gram-positive bacteria. S-layer glycoproteins have the unique feature of self-assembling into 2D lattices providing a display matrix for glycans with periodicity at the nanometer scale. Typically, bacterial S-layer glycans are O-glycosidically linked to serine, threonine, or tyrosine residues, and they rely on a much wider variety of constituents, glycosidic linkage types, and structures than their eukaryotic counterparts. As the S-layer glycome of several bacteria is unravelling, a picture of how S-layer glycoproteins are biosynthesized is evolving. X-ray crystallography experiments allowed first insights into the catalysis mechanism of selected enzymes. In the future, it will be exciting to fully exploit the S-layer glycome for glycoengineering purposes and to link it to the bacterial interactome.
Authors:
Robin Ristl; Kerstin Steiner; Kristof Zarschler; Sonja Zayni; Paul Messner; Christina Schäffer
Publication Detail:
Type:  Journal Article     Date:  2010-08-10
Journal Detail:
Title:  International journal of microbiology     Volume:  2011     ISSN:  1687-9198     ISO Abbreviation:  Int J Microbiol     Publication Date:  2011  
Date Detail:
Created Date:  2010-09-27     Completed Date:  2011-07-14     Revised Date:  2011-09-15    
Medline Journal Info:
Nlm Unique ID:  101516125     Medline TA:  Int J Microbiol     Country:  Egypt    
Other Details:
Languages:  eng     Pagination:  -     Citation Subset:  -    
Affiliation:
Department of NanoBiotechnology, Vienna Institute of BioTechnology, University of Natural Resources and Life Sciences, Muthgasse 11, 1190 Vienna, Austria.
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Grant Support
ID/Acronym/Agency:
P 19047-B12//Austrian Science Fund FWF; P 20605-B12//Austrian Science Fund FWF; P 20745-B11//Austrian Science Fund FWF; P 21954-B20//Austrian Science Fund FWF

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