Document Detail


The runner's high: opioidergic mechanisms in the human brain.
MedLine Citation:
PMID:  18296435     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The runner's high describes a euphoric state resulting from long-distance running. The cerebral neurochemical correlates of exercise-induced mood changes have been barely investigated so far. We aimed to unravel the opioidergic mechanisms of the runner's high in the human brain and to identify the relationship to perceived euphoria. We performed a positron emission tomography "ligand activation" study with the nonselective opioidergic ligand 6-O-(2-[(18)F]fluoroethyl)-6-O-desmethyldiprenorphine ([(18)F]FDPN). Ten athletes were scanned at 2 separate occasions in random order, at rest and after 2 h of endurance running (21.5 +/- 4.7 km). Binding kinetics of [(18)F]FDPN were quantified by basis pursuit denoising (DEPICT software). Statistical parametric mapping (SPM2) was used for voxelwise analyses to determine relative changes in ligand binding after running and correlations of opioid binding with euphoria ratings. Reductions in opioid receptor availability were identified preferentially in prefrontal and limbic/paralimbic brain structures. The level of euphoria was significantly increased after running and was inversely correlated with opioid binding in prefrontal/orbitofrontal cortices, the anterior cingulate cortex, bilateral insula, parainsular cortex, and temporoparietal regions. These findings support the "opioid theory" of the runner's high and suggest region-specific effects in frontolimbic brain areas that are involved in the processing of affective states and mood.
Authors:
Henning Boecker; Till Sprenger; Mary E Spilker; Gjermund Henriksen; Marcus Koppenhoefer; Klaus J Wagner; Michael Valet; Achim Berthele; Thomas R Tolle
Related Documents :
8884225 - Binding of [3h](+)-bw373u86 to delta-opioid receptors in rat brain membranes.
6128655 - Binding characteristics of mu and kappa agonists in rat brain subcellular fractions.
2575315 - Effect of n-ethylmaleimide treatment on naloxone binding in frog brain membranes.
6724805 - In vitro interaction of opioid peptides with phospholipids. formation and characterizat...
3784915 - Evidence for dopaminergic binding sites in the human adrenal cortex.
1180105 - Cholinergic receptors at denervated mammalian motor end-plates.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-02-21
Journal Detail:
Title:  Cerebral cortex (New York, N.Y. : 1991)     Volume:  18     ISSN:  1460-2199     ISO Abbreviation:  Cereb. Cortex     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-16     Completed Date:  2008-12-22     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9110718     Medline TA:  Cereb Cortex     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2523-31     Citation Subset:  IM    
Affiliation:
Nuklearmedizinische Klinik, Klinikum rechts der Isar, Technische Universität München, 81675 München, Germany. henning.boecker@ukb.uni-bonn.de
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Adult
Diprenorphine / analogs & derivatives,  diagnostic use
Euphoria / physiology*
Exercise / physiology,  psychology
Humans
Limbic System / physiology*,  radionuclide imaging
Male
Opioid Peptides / physiology*
Physical Endurance / physiology
Pilot Projects
Positron-Emission Tomography
Prefrontal Cortex / physiology*,  radionuclide imaging
Running / physiology*,  psychology
Chemical
Reg. No./Substance:
0/6-O-(2-(18F)fluoroethyl)-6-O-desmethyldiprenorphine; 0/Opioid Peptides; 14357-78-9/Diprenorphine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Functional coactivation map of the human brain.
Next Document:  Kinesthetic imagery and tool-specific modulation of corticospinal representations in expert tennis p...