Document Detail


The rules of variation: amino acid exchange according to the rotating circular genetic code.
MedLine Citation:
PMID:  20371250     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
General guidelines for the molecular basis of functional variation are presented while focused on the rotating circular genetic code and allowable exchanges that make it resistant to genetic diseases under normal conditions. The rules of variation, bioinformatics aids for preventative medicine, are: (1) same position in the four quadrants for hydrophobic codons, (2) same or contiguous position in two quadrants for synonymous or related codons, and (3) same quadrant for equivalent codons. To preserve protein function, amino acid exchange according to the first rule takes into account the positional homology of essential hydrophobic amino acids with every codon with a central uracil in the four quadrants, the second rule includes codons for identical, acidic, or their amidic amino acids present in two quadrants, and the third rule, the smaller, aromatic, stop codons, and basic amino acids, each in proximity within a 90 degree angle. I also define codifying genes and palindromati, CTCGTGCCGAATTCGGCACGAG.
Authors:
Fernando Castro-Chavez
Publication Detail:
Type:  Journal Article     Date:  2010-04-03
Journal Detail:
Title:  Journal of theoretical biology     Volume:  264     ISSN:  1095-8541     ISO Abbreviation:  J. Theor. Biol.     Publication Date:  2010 Jun 
Date Detail:
Created Date:  2010-05-11     Completed Date:  2010-08-20     Revised Date:  2013-05-29    
Medline Journal Info:
Nlm Unique ID:  0376342     Medline TA:  J Theor Biol     Country:  England    
Other Details:
Languages:  eng     Pagination:  711-21     Citation Subset:  IM    
Copyright Information:
Copyright (c) 2010 Elsevier Ltd. All rights reserved.
Affiliation:
Universidad de Guadalajara, Centro Universitario de la Costa, Puerto Vallarta, Mexico. fdocc@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Amino Acids / genetics*
Animals
Base Sequence
Codon / genetics*
Genetic Code / genetics*
Genetic Variation
Humans
Models, Genetic*
Grant Support
ID/Acronym/Agency:
T32 HL007812-11/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
0/Amino Acids; 0/Codon
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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