| The rules of variation: amino acid exchange according to the rotating circular genetic code. | |
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MedLine Citation:
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PMID: 20371250 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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General guidelines for the molecular basis of functional variation are presented while focused on the rotating circular genetic code and allowable exchanges that make it resistant to genetic diseases under normal conditions. The rules of variation, bioinformatics aids for preventative medicine, are: (1) same position in the four quadrants for hydrophobic codons, (2) same or contiguous position in two quadrants for synonymous or related codons, and (3) same quadrant for equivalent codons. To preserve protein function, amino acid exchange according to the first rule takes into account the positional homology of essential hydrophobic amino acids with every codon with a central uracil in the four quadrants, the second rule includes codons for identical, acidic, or their amidic amino acids present in two quadrants, and the third rule, the smaller, aromatic, stop codons, and basic amino acids, each in proximity within a 90 degree angle. I also define codifying genes and palindromati, CTCGTGCCGAATTCGGCACGAG. |
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Authors:
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Fernando Castro-Chavez |
Publication Detail:
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Type: Journal Article Date: 2010-04-03 |
Journal Detail:
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Title: Journal of theoretical biology Volume: 264 ISSN: 1095-8541 ISO Abbreviation: J. Theor. Biol. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-11 Completed Date: 2010-08-20 Revised Date: 2011-08-01 |
Medline Journal Info:
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Nlm Unique ID: 0376342 Medline TA: J Theor Biol Country: England |
Other Details:
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Languages: eng Pagination: 711-21 Citation Subset: IM |
Copyright Information:
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Copyright (c) 2010 Elsevier Ltd. All rights reserved. |
Affiliation:
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Universidad de Guadalajara, Centro Universitario de la Costa, Puerto Vallarta, Mexico. fdocc@yahoo.com |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Amino Acids
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genetics* Animals Base Sequence Codon / genetics* Genetic Code / genetics* Genetic Variation Humans Models, Genetic* |
| Grant Support | |
ID/Acronym/Agency:
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T32 HL007812-11/HL/NHLBI NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Amino Acids; 0/Codon |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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