Document Detail

Is routine measurement of amylase concentration in drainage fluid necessary after total gastrectomy for gastric cancer?
MedLine Citation:
PMID:  21495031     Owner:  NLM     Status:  Publisher    
BACKGROUND AND OBJECTIVES: Measurement of amylase level in drainage fluid (D-AMY) is often performed for detection of pancreatic fistula (PF) formation after total gastrectomy. However, PF incidence has decreased and PF formation can be judged by changes in drainage fluid properties. The aim of study is to compare the significance of drainage fluid inspection for PF formation with D-AMY measurement. METHODS: PF incidence, drainage fluid properties, and D-AMY level in drainage fluid were investigated retrospectively in 173 patients undergoing total gastrectomy for gastric cancer. The sensitivity and specificity of changes in fluid properties for PF detection were compared to D-AMY measurement. RESULTS: PF incidence in patients with dark-red colored drainage fluid (16/51) was higher than in those without dark-red fluid (0/122, P < 0.0001). The sensitivity and specificity of diagnosis by fluid properties were 100% and 77.7%, respectively. PF formation also correlated with D-AMY level, with sensitivity and specificity of diagnosis by D-AMY level of 5,000 U of 100% and 82.2%, respectively. There were no differences in the above parameters between the two diagnostic methods. CONCLUSIONS: Drainage fluid inspection can provide accurate diagnosis of PF formation, similar to D-AMY measurement, suggesting that routine D-AMY measurement is probably not necessary in every patient. J. Surg. Oncol. © 2011 Wiley-Liss, Inc.
Yoshito Tomimaru; Isao Miyashiro; Kentaro Kishi; Masaaki Motoori; Masahiko Yano; Tatsushi Shingai; Shingo Noura; Masayuki Ohue; Hiroaki Ohigashi; Osamu Ishikawa
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-4-14
Journal Detail:
Title:  Journal of surgical oncology     Volume:  -     ISSN:  1096-9098     ISO Abbreviation:  -     Publication Date:  2011 Apr 
Date Detail:
Created Date:  2011-4-15     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0222643     Medline TA:  J Surg Oncol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2011 Wiley-Liss, Inc.
Department of Surgery, Osaka Medical Center for Cancer and Cardiovascular Diseases, Osaka, Japan; Department of Surgery, Graduate School of Medicine, Osaka University, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Heme oxygenase-1 germ line GTn promoter polymorphism is an independent prognosticator of tumor recur...
Next Document:  Analysis of microRNA expression profiling identifies microRNA-503 regulates metastatic function in h...