Document Detail


A round robin exercise in archaeometry: analysis of a blind sample reproducing a seventeenth century pharmaceutical ointment.
MedLine Citation:
PMID:  21667062     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Chemical analysis of ancient residues of pharmaceutical or cosmetic preparations such as balms or ointments is made problematic by the high complexity of these mixtures, composed of organic and inorganic materials. Consequently, a multi-analytical approach and special caution in the interpretation of the results are necessary. In order to contribute to the improvement of analytical strategies for the characterization of complex residues and to reconstruct ancient medical practices, a replica of a pharmaceutical formulation of the seventeenth century was prepared in the laboratory according to a historically documented recipe. In a round robin exercise, a portion of the preparation was analysed as a blind sample by 11 laboratories using various analytical techniques. These included spectroscopic, chromatographic and mass spectrometric methods. None of the laboratories was able to completely reconstruct the complex formulation, but each of them gave partial positive results. The round robin exercise has demonstrated that the application of a multi-analytical approach can permit a complete and reliable reconstruction of the composition. Finally, on the basis of the results, an analytical protocol for the study of residues of ancient medical and pharmaceutical preparations has been outlined.
Authors:
M P Colombini; F Modugno; M C Gamberini; M Rocchi; C Baraldi; T Deviese; R J Stacey; M Orlandi; F Saliu; C Riedo; O Chiantore; G Sciutto; E Catelli; L Brambilla; L Toniolo; C Miliani; P Rocchi; J Bleton; U Baumer; P Dietemann; G Pojana; S Marras
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2011-6-11
Journal Detail:
Title:  Analytical and bioanalytical chemistry     Volume:  -     ISSN:  1618-2650     ISO Abbreviation:  -     Publication Date:  2011 Jun 
Date Detail:
Created Date:  2011-6-13     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101134327     Medline TA:  Anal Bioanal Chem     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Affiliation:
Dipartimento di Chimica, SCIBEC, Università di Pisa, 56126, Pisa, Italy, perla@dcci.unipi.it.
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