Document Detail

The rolling circle for phi X DNA replication. 3. Synthesis of supercoiled duplex rings.
MedLine Citation:
PMID:  5272326     Owner:  NLM     Status:  MEDLINE    
During varphiX duplex ring synthesis, the first supercoils to acquire radioactivity after the addition of tritiated thymidine are labeled only in their negative strands. In longer pulses, this asymmetry of labeling progressively disappears. This finding supports the rolling circle model for DNA replication due to the structural asymmetry of its replicating intermediate, but is not predicted by the Cairns or Yoshikawa models.
D Dressler; J Wolfson
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  67     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1970 Sep 
Date Detail:
Created Date:  1970-11-05     Completed Date:  1970-11-05     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  456-63     Citation Subset:  IM    
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MeSH Terms
Carbon Isotopes
Centrifugation, Density Gradient
Coliphages / metabolism*
DNA Replication*
Phosphorus Isotopes
Reg. No./Substance:
0/Carbon Isotopes; 0/Phosphorus Isotopes; 10028-17-8/Tritium; 50-89-5/Thymidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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