| The rolling circle for phi X DNA replication. 3. Synthesis of supercoiled duplex rings. | |
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MedLine Citation:
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PMID: 5272326 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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During varphiX duplex ring synthesis, the first supercoils to acquire radioactivity after the addition of tritiated thymidine are labeled only in their negative strands. In longer pulses, this asymmetry of labeling progressively disappears. This finding supports the rolling circle model for DNA replication due to the structural asymmetry of its replicating intermediate, but is not predicted by the Cairns or Yoshikawa models. |
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Authors:
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D Dressler; J Wolfson |
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Publication Detail:
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Type: Journal Article |
Journal Detail:
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Title: Proceedings of the National Academy of Sciences of the United States of America Volume: 67 ISSN: 0027-8424 ISO Abbreviation: Proc. Natl. Acad. Sci. U.S.A. Publication Date: 1970 Sep |
Date Detail:
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Created Date: 1970-11-05 Completed Date: 1970-11-05 Revised Date: 2009-11-18 |
Medline Journal Info:
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Nlm Unique ID: 7505876 Medline TA: Proc Natl Acad Sci U S A Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 456-63 Citation Subset: IM |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Carbon Isotopes Centrifugation, Density Gradient Coliphages / metabolism* DNA Replication* Phosphorus Isotopes Thymidine Tritium |
| Chemical | |
Reg. No./Substance:
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0/Carbon Isotopes; 0/Phosphorus Isotopes; 10028-17-8/Tritium; 50-89-5/Thymidine |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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