| The roles of telomeres and telomerase in beta-cell regeneration. | |
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MedLine Citation:
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PMID: 19817785 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
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Telomerase is a specialized reverse transcriptase that is responsible for extending and preserving the end of the chromosomes (telomeres). Telomerase plays a key role in regulating the lifespan of mammalian cells and is involved in critical aspects of cellular ageing processes. In this review, we will briefly summarize our current understanding of the functions of telomeres, telomerase and their regulation. Considering that compensatory islet hyperplasia and beta-cell regeneration play important roles in the prevention and/or delay of the onset of overt diabetes, we will also examine current literature regarding the effects of diabetes on telomere shortening and provide insights from our own studies on the role of telomerase in beta-cell regeneration. |
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Authors:
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C W Liew; A Holman; R N Kulkarni |
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Publication Detail:
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Type: Journal Article; Research Support, N.I.H., Extramural |
Journal Detail:
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Title: Diabetes, obesity & metabolism Volume: 11 Suppl 4 ISSN: 1463-1326 ISO Abbreviation: Diabetes Obes Metab Publication Date: 2009 Nov |
Date Detail:
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Created Date: 2009-10-12 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 100883645 Medline TA: Diabetes Obes Metab Country: England |
Other Details:
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Languages: eng Pagination: 21-9 Citation Subset: IM |
Affiliation:
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Joslin Diabetes Center and Department of Medicine, Harvard Medical School, Boston, MA, USA. |
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Descriptor/Qualifier:
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| Grant Support | |
ID/Acronym/Agency:
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1RL9EB008539-01/EB/NIBIB NIH HHS; R01 DK 67536/DK/NIDDK NIH HHS; R01 DK 68721/DK/NIDDK NIH HHS |
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