Document Detail


The roles of a novel inflammatory neopterin in subjects with coronary atherosclerotic heart disease.
MedLine Citation:
PMID:  25479720     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Coronary atherosclerotic heart disease is currently regarded as a chronic inflammatory disease, and the inflammatory response is closely related to the stability of the plaque. The inflammatory cytokine neopterin (NP) is a new predictor of the stable type of atherosclerotic plaque, and this study focused on the relationship between neopterin, Gensini score and high-sensitivity C-reactive protein (Hs-CRP) to explore the important role of neopterin in patients with coronary heart disease. This study enrolled 176 patients into the control group and 266 patients into the experimental group. The Gensini score was used to assess the severity of the coronary lesions in patients with coronary heart disease, enzyme-linked immunosorbent assays (ELISAs) were used to measure the serum NP level, and other indicators were assessed using a fully automatic biochemical analyzer. The data were analyzed using SPSS19.0 statistical software. The serum NP level was higher in the experimental group than in the control group (132.23±6.40ng/mL vs. 40.95±2.67ng/mL, P<0.001), and the NP level was positively correlated with the severity of coronary heart disease. Compared with the stable angina (SA) group, the serum NP level was significantly increased in the unstable angina (UA) group (135.99±12.45ng/mL) and the acute myocardial infarction (AMI) group (173.66±13.59ng/mL) (P<0.05). In addition, the serum NP level was positively correlated with the Gensini score (r=0.687, P<0.001) as well as with the level of Hs-CRP (r=0.190, P<0.001). The results of this study showed that the serum level of NP, an inflammatory cytokine, was significantly higher in patients with coronary heart disease and was positively correlated with the severity of coronary artery disease. Thus, NP may become a new indicator for the assessment of the inflammatory response in coronary atherosclerosis.
Authors:
Yongnan Lyu; Xuejun Jiang; Wen Dai
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-25
Journal Detail:
Title:  International immunopharmacology     Volume:  -     ISSN:  1878-1705     ISO Abbreviation:  Int. Immunopharmacol.     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-6     Completed Date:  -     Revised Date:  2014-12-7    
Medline Journal Info:
Nlm Unique ID:  100965259     Medline TA:  Int Immunopharmacol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2014. Published by Elsevier B.V.
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