Document Detail


The roles of individual polyoma virus early proteins in oncogenic transformation.
MedLine Citation:
PMID:  6294529     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The expression in normal rat cells of modified polyoma virus genomes, separately encoding large T, middle T or small T antigens, has allowed the investigation of the roles of these proteins in oncogenic transformation. Middle T is sufficient to transform cells of established lines but the transformants are serum dependent. Large T lacks intrinsic oncogenic potential but can relieve the serum dependence of normal and transformed cells. Middle T alone cannot transform primary rat embryo fibroblasts.
Authors:
M Rassoulzadegan; A Cowie; A Carr; N Glaichenhaus; R Kamen; F Cuzin
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Nature     Volume:  300     ISSN:  0028-0836     ISO Abbreviation:  Nature     Publication Date:  1982 Dec 
Date Detail:
Created Date:  1983-02-14     Completed Date:  1983-02-14     Revised Date:  2003-11-14    
Medline Journal Info:
Nlm Unique ID:  0410462     Medline TA:  Nature     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  713-8     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Animals
Antigens, Viral / genetics*
Antigens, Viral, Tumor
Cell Transformation, Neoplastic*
Cell Transformation, Viral*
Cells, Cultured
Culture Media
DNA, Viral / genetics
Oncogenes
Polyomavirus / genetics,  immunology
Rats
Viral Proteins / physiology*
Chemical
Reg. No./Substance:
0/Antigens, Viral; 0/Antigens, Viral, Tumor; 0/Culture Media; 0/DNA, Viral; 0/Viral Proteins

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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