Document Detail


The roles of cells and cytokines in the pathogenesis of psoriasis.
MedLine Citation:
PMID:  22435425     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Psoriasis is considered an immune chronic disease in which T cells are accepted as important. Nowadays, it is believed that psoriasis is most likely a T helper (Th)1/Th17 induced inflammatory disease. However, some other cells, such as endothelial cells, dendritic cells, monocytic cells, neutrophils, keratinocytes, and several cytokines, appear to have, at different stages of the disease, an important role in its pathogenesis. For instance, the response to psoriasis therapy is dependent not only on the inactivation of Th1 and Th17 immune responses but also on the inactivation of dendritic cell products. Moreover, interleukin (IL)-23 deregulation appears to be an independent factor in the pathogenesis of psoriasis. Indeed, currently, the IL-23/Th17 axis is believed to be crucial in psoriasis pathogenesis, and its inhibition appears to be important for therapeutic achievement. This review presents the roles and interactions of cells and cytokines that are related to psoriasis pathogenesis.
Authors:
Susana Coimbra; Américo Figueiredo; Elisabeth Castro; Petronila Rocha-Pereira; Alice Santos-Silva
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Publication Detail:
Type:  JOURNAL ARTICLE    
Journal Detail:
Title:  International journal of dermatology     Volume:  51     ISSN:  1365-4632     ISO Abbreviation:  -     Publication Date:  2012 Apr 
Date Detail:
Created Date:  2012-3-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0243704     Medline TA:  Int J Dermatol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  389-398     Citation Subset:  -    
Copyright Information:
© 2012 The International Society of Dermatology.
Affiliation:
Biochemistry Laboratory, Department of Biological Science, Faculty of Pharmacy and Institute of Molecular and Cellular Biology (Instituto de Biologia Molecular e Celular [IBMC]), University of Porto (Universidade do Porto), Porto, Portugal Centre for Investigation into Health Technologies (Centro de Investigação das Tecnologias da Saúde [CITS]), Northern Polytechnic Health Institute (Instituto Politécnico da Saúde Norte), Cooperative Higher Education, Polytechnic and University (Cooperativa de Ensino Superior, Politécnico e Universitário [CESPU]), Gandra-Paredes, Portugal Dermatology Service, Coimbra University Hospital (Hospitais da Universidade de Coimbra), Coimbra, Portugal Centre for Investigation in Health Sciences (Centro de Investigação em Ciências da Saúde [CICS]), University of Beira Interior (Universidade da Beira Interior), Covilhã, Portugal.
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