Document Detail

The roles of PTEN in development, physiology and tumorigenesis in mouse models: a tissue-by-tissue survey.
MedLine Citation:
PMID:  18794876     Owner:  NLM     Status:  MEDLINE    
In 1997, PTEN (phosphatase and tensin homologue deleted on chromosome 10, 10q23.3) was identified as an important tumor suppressor gene that is inactivated in a wide variety of human cancers. Ever since, PTEN's function has been extensively studied, and huge progress has been made in understanding PTEN's role in normal physiology and disease. In this review, we will systematically summarize the important data that have been gained from gene inactivation studies in mice and will put these data into physiological context using a tissue-by-tissue approach. We will cover mice exhibiting complete and constitutive inactivation of Pten as well as a large number of strains in which Pten has been conditionally deleted in specific tissues. We hope to highlight not only the tumor suppressive function of Pten but also its roles in embryogenesis and in the maintenance of the normal physiological functions of many organ systems.
C B Knobbe; V Lapin; A Suzuki; T W Mak
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  Oncogene     Volume:  27     ISSN:  1476-5594     ISO Abbreviation:  Oncogene     Publication Date:  2008 Sep 
Date Detail:
Created Date:  2008-09-16     Completed Date:  2008-10-08     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  8711562     Medline TA:  Oncogene     Country:  England    
Other Details:
Languages:  eng     Pagination:  5398-415     Citation Subset:  IM    
Campbell Family Institute for Breast Cancer Research, University of Toronto, 620 University Avenue, Toronto, Ontario, Canada.
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MeSH Terms
Cell Physiological Phenomena*
Cell Transformation, Neoplastic / genetics*
Embryonic Development / genetics,  physiology
Growth and Development / genetics*
Mice / genetics*
Mice, Knockout
Models, Animal
Organ Specificity / genetics*
PTEN Phosphohydrolase / genetics,  physiology*
Reg. No./Substance:
EC Phosphohydrolase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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