Document Detail


The role of xanthine oxidase in paraquat intoxication.
MedLine Citation:
PMID:  1654824     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The role of xanthine oxidase in the mechanism of paraquat toxicity was assessed by in vitro and in vivo experiments. Paraquat stimulated the reduction of cytochrome c by xanthine-xanthine oxidase system in vitro. Paraquat, when added in vitro, stimulated hypoxanthine-dependent superoxide production in the cytosol of rat lung. Tungsten-feeding inhibits xanthine oxidase activity in a variety of tissues in experimental animals. Its therapeutic effect on paraquat intoxication was studied in this paper. In rats fed a tungsten-enriched diet for 5 weeks prior to intraperitoneal injection of 50 mg/kg paraquat dichloride, the mortality decreased significantly compared with rats fed a standard diet. Pretreatment with oxypurinol (1000 mg/kg, s.c.) also ameliorated the paraquat toxicity in rats. We conclude that xanthine oxidase plays an important role in paraquat toxicity and that xanthine oxidase inhibitors may become antidotes for paraquat intoxication.
Authors:
Y Kitazawa; M Matsubara; N Takeyama; T Tanaka
Related Documents :
9519684 - Preparation and pharmacological evaluation of physostigmine-loaded polyisobutylcyanoacr...
3123604 - Selegiline and the prophylaxis of parkinson's disease.
13687054 - Effects on amine oxidase of substances which antagonize 5-hydroxytryptamine more than t...
288344 - Monoamine oxidase inhibiting and toxic effects of acetyl-phenylhydrazide on rat liver i...
3879174 - Influence of (+)-propoxyphene on the hexachlorobenzene-induced porphyria of rats.
430174 - In vivo measurement of liver perfusion in the normal and partially hepatectomized rat u...
Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  288     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Affiliation:
Department of Emergency, Kansai Medical University, Osaka, Japan.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Descriptor/Qualifier:
Animals
Cytochrome c Group / metabolism
Lung / drug effects,  metabolism
Male
Oxypurinol / pharmacology
Paraquat / antagonists & inhibitors,  toxicity*
Rats
Rats, Inbred Strains
Superoxides / metabolism
Thiobarbiturates / metabolism
Tungsten / pharmacology
Xanthine Dehydrogenase / metabolism
Xanthine Oxidase / metabolism*
Chemical
Reg. No./Substance:
0/Cytochrome c Group; 0/Thiobarbiturates; 11062-77-4/Superoxides; 2465-59-0/Oxypurinol; 4685-14-7/Paraquat; 504-17-6/thiobarbituric acid; 7440-33-7/Tungsten; EC 1.17.1.4/Xanthine Dehydrogenase; EC 1.17.3.2/Xanthine Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


Previous Document:  Mn(III)-desferrioxamine superoxide dismutase-mimic: alternative modes of action.
Next Document:  Activation of phosphoinositide-specific phospholipase C delta from rat liver by polyamines and basic...