Document Detail

The role of xanthine oxidase in paraquat intoxication.
MedLine Citation:
PMID:  1654824     Owner:  NLM     Status:  MEDLINE    
The role of xanthine oxidase in the mechanism of paraquat toxicity was assessed by in vitro and in vivo experiments. Paraquat stimulated the reduction of cytochrome c by xanthine-xanthine oxidase system in vitro. Paraquat, when added in vitro, stimulated hypoxanthine-dependent superoxide production in the cytosol of rat lung. Tungsten-feeding inhibits xanthine oxidase activity in a variety of tissues in experimental animals. Its therapeutic effect on paraquat intoxication was studied in this paper. In rats fed a tungsten-enriched diet for 5 weeks prior to intraperitoneal injection of 50 mg/kg paraquat dichloride, the mortality decreased significantly compared with rats fed a standard diet. Pretreatment with oxypurinol (1000 mg/kg, s.c.) also ameliorated the paraquat toxicity in rats. We conclude that xanthine oxidase plays an important role in paraquat toxicity and that xanthine oxidase inhibitors may become antidotes for paraquat intoxication.
Y Kitazawa; M Matsubara; N Takeyama; T Tanaka
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Publication Detail:
Type:  In Vitro; Journal Article    
Journal Detail:
Title:  Archives of biochemistry and biophysics     Volume:  288     ISSN:  0003-9861     ISO Abbreviation:  Arch. Biochem. Biophys.     Publication Date:  1991 Jul 
Date Detail:
Created Date:  1991-10-24     Completed Date:  1991-10-24     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  0372430     Medline TA:  Arch Biochem Biophys     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  220-4     Citation Subset:  IM    
Department of Emergency, Kansai Medical University, Osaka, Japan.
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MeSH Terms
Cytochrome c Group / metabolism
Lung / drug effects,  metabolism
Oxypurinol / pharmacology
Paraquat / antagonists & inhibitors,  toxicity*
Rats, Inbred Strains
Superoxides / metabolism
Thiobarbiturates / metabolism
Tungsten / pharmacology
Xanthine Dehydrogenase / metabolism
Xanthine Oxidase / metabolism*
Reg. No./Substance:
0/Cytochrome c Group; 0/Thiobarbiturates; 11062-77-4/Superoxides; 2465-59-0/Oxypurinol; 4685-14-7/Paraquat; 504-17-6/thiobarbituric acid; 7440-33-7/Tungsten; EC Dehydrogenase; EC Oxidase

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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