| The role of voluntary exercise in enriched rearing: a behavioral analysis. | |
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MedLine Citation:
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PMID: 16893285 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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The effects of postweaning enriched rearing and home cage voluntary wheel-running exercise in adulthood were contrasted on a comprehensive battery of tests designed to assess mnemonic, attentional, emotional, and motor functions. In a 2 x 2 factorial design, female C57BL/6 mice were housed in groups in either standard or enriched cages, which were equipped with either a running or a locked wheel. They were maintained in the corresponding housing conditions for 2 months postweaning prior to, and throughout, testing. Enriched rearing was associated with anxiogenesis, hypolocomotor activity, enhanced motor skills, retarded extinction of conditioned responding, and improved water maze performance. Exercise as such enhanced motor coordination and facilitated extinction of contextual conditioning. Evidence for an interaction between enrichment and exercise was apparent in the open field test, conditioned freezing to a tone stimulus, prepulse inhibition, and acquisition of water maze reference memory. Hence, care should be taken to control for the unique contribution of wheel-running exercise when it is included as an integral component of the enrichment procedure. |
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Authors:
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Susanna Pietropaolo; Joram Feldon; Enrico Alleva; Francesca Cirulli; Benjamin K Yee |
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Publication Detail:
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Type: Comparative Study; Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Behavioral neuroscience Volume: 120 ISSN: 0735-7044 ISO Abbreviation: Behav. Neurosci. Publication Date: 2006 Aug |
Date Detail:
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Created Date: 2006-08-08 Completed Date: 2006-09-28 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8302411 Medline TA: Behav Neurosci Country: United States |
Other Details:
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Languages: eng Pagination: 787-803 Citation Subset: IM |
Copyright Information:
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Copyright 2006 APA, all rights reserved. |
Affiliation:
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Laboratory of Behavioral Neurobiology, Swiss Federal Institute of Technology Zurich, Schwerzenbach, Switzerland. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Analysis of Variance Animals Animals, Newborn Behavior, Animal / physiology* Conditioning, Classical / physiology Environment* Exploratory Behavior / physiology Female Freezing Reaction, Cataleptic / physiology Maze Learning / physiology Mice Mice, Inbred C57BL Motor Activity / physiology* Neural Inhibition / physiology Physical Conditioning, Animal / methods*, psychology* Reaction Time / physiology Rotarod Performance Test / methods Space Perception / physiology Startle Reaction / physiology |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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