Document Detail

The role of vitamin E in the prevention of coronary events and stroke. Meta-analysis of randomized controlled trials.
MedLine Citation:
PMID:  15711645     Owner:  NLM     Status:  MEDLINE    
Cardiovascular disease (CVD) is the leading cause of morbidity and mortality in the world. Vitamin E as an anti-oxidant vitamin, was suggested to have a role in the prevention of CVD. We did a meta-analysis, using the Cochrane Group Methodology, of all available randomized controlled trials (RCTs) to evaluate the role of vitamin E in the prevention of CVD. Nine studies met inclusion criteria, including 80,645 participants. Vitamin E supplementation was not associated with a reduction in total mortality or total CVD mortality, but it was associated with a small statistically significant reduction in non-fatal myocardial infarction in patients with pre-existing coronary artery disease. Prophylactic use of vitamin E in doses ranging between 50-800 IU was not associated with any increase in the incidence of serious side effects.
Abdullah H Alkhenizan; Mohammed A Al-Omran
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Publication Detail:
Type:  Journal Article; Meta-Analysis    
Journal Detail:
Title:  Saudi medical journal     Volume:  25     ISSN:  0379-5284     ISO Abbreviation:  Saudi Med J     Publication Date:  2004 Dec 
Date Detail:
Created Date:  2005-02-15     Completed Date:  2005-04-08     Revised Date:  2008-06-23    
Medline Journal Info:
Nlm Unique ID:  7909441     Medline TA:  Saudi Med J     Country:  Saudi Arabia    
Other Details:
Languages:  eng     Pagination:  1808-14     Citation Subset:  IM    
Department of Family Medicine and Polyclinic, King Faisal Specialist Hospital and Research Centre, Riyadh, Kingdom of Saudi Arabia.
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MeSH Terms
Antioxidants / administration & dosage*
Coronary Disease / mortality,  prevention & control*
Myocardial Infarction / mortality,  prevention & control
Randomized Controlled Trials as Topic
Stroke / mortality,  prevention & control*
Treatment Outcome
Vitamin E / administration & dosage*
Reg. No./Substance:
0/Antioxidants; 1406-18-4/Vitamin E

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