Document Detail

The role of vitamin D in paediatric bone health.
MedLine Citation:
PMID:  21872799     Owner:  NLM     Status:  MEDLINE    
Recently there has been renewed interest in the role of vitamin D in paediatric bone health. Its role in the development of rickets and hypocalcaemia in infants and young children, in particular, in many part of the world is well known, and the importance of the prevention of vitamin D deficiency during pregnancy and lactation has been highlighted. Less clear are the possible effects that maintaining maternal vitamin D sufficiency might have on foetal and early infant growth and bone development. There is little evidence to suggest that maintaining childhood vitamin D status well above that necessary to prevent rickets has an effect on intestinal calcium absorption or on peak bone mass. Further studies are needed in these areas prior to definitive conclusions are drawn about the optimal vitamin D requirements and circulating 25(OH)D concentrations for foetal, infant and childhood bone health.
John M Pettifor; Ann Prentice
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Publication Detail:
Type:  Journal Article; Review    
Journal Detail:
Title:  Best practice & research. Clinical endocrinology & metabolism     Volume:  25     ISSN:  1878-1594     ISO Abbreviation:  Best Pract. Res. Clin. Endocrinol. Metab.     Publication Date:  2011 Aug 
Date Detail:
Created Date:  2011-08-29     Completed Date:  2012-01-03     Revised Date:  2014-02-20    
Medline Journal Info:
Nlm Unique ID:  101120682     Medline TA:  Best Pract Res Clin Endocrinol Metab     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  573-84     Citation Subset:  IM    
Copyright Information:
Copyright © 2011 Elsevier Ltd. All rights reserved.
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MeSH Terms
Adolescent Development*
Bone Development*
Calcium, Dietary / metabolism
Child Development*
Child, Preschool
Infant, Newborn
Intestinal Absorption
Maternal Nutritional Physiological Phenomena
Muscle Strength
Rickets / diagnosis,  physiopathology,  prevention & control,  therapy
Vitamin D / administration & dosage,  metabolism*,  therapeutic use
Vitamin D Deficiency / physiopathology
Grant Support
MC_U105960371//Medical Research Council
Reg. No./Substance:
0/Calcium, Dietary; 1406-16-2/Vitamin D

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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