Document Detail


The role of the visceral mesoderm in the development of the gastrointestinal tract.
MedLine Citation:
PMID:  19303014     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The gastrointestinal (GI) tract forms from the endoderm (which gives rise to the epithelium) and the mesoderm (which develops into the smooth muscle layer, the mesenchyme, and numerous other cell types). Much of what is known of GI development has been learned from studies of the endoderm and its derivatives, because of the importance of epithelial biology in understanding and treating human diseases. Although the necessity of epithelial-mesenchymal cross talk for GI development is uncontested, the role of the mesoderm remains comparatively less well understood. The transformation of the visceral mesoderm during development is remarkable; it differentiates from a very thin layer of cells into a complex tissue comprising smooth muscle cells, myofibroblasts, neurons, immune cells, endothelial cells, lymphatics, and extracellular matrix molecules, all contributing to the form and function of the digestive system. Understanding the molecular processes that govern the development of these cell types and elucidating their respective contribution to GI patterning could offer insight into the mechanisms that regulate cell fate decisions in the intestine, which has the unique property of rapid cell renewal for the maintenance of epithelial integrity. In reviewing evidence from both mammalian and nonmammalian models, we reveal the important role of the visceral mesoderm in the ontogeny of the GI tract.
Authors:
Valérie A McLin; Susan J Henning; Milan Jamrich
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, Non-U.S. Gov't; Review     Date:  2009-03-17
Journal Detail:
Title:  Gastroenterology     Volume:  136     ISSN:  1528-0012     ISO Abbreviation:  Gastroenterology     Publication Date:  2009 Jun 
Date Detail:
Created Date:  2009-06-08     Completed Date:  2009-07-08     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0374630     Medline TA:  Gastroenterology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2074-91     Citation Subset:  AIM; IM    
Affiliation:
Department of Pediatrics, Section of Gastroenterology, Hepatology and Nutrition, Baylor College of Medicine, Houston, Texas, USA. valerie.mclin@hcuge.ch
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MeSH Terms
Descriptor/Qualifier:
Animals
Chick Embryo
Embryonic Development / physiology*
Fetal Development
Gastrointestinal Tract / embryology*,  physiology
Intestine, Large / embryology
Intestine, Small / embryology
Mesoderm / embryology*,  physiology
Mice
Models, Animal
Species Specificity
Stomach / embryology
Xenopus
Grant Support
ID/Acronym/Agency:
K08DK078656/DK/NIDDK NIH HHS; R01DK069585/DK/NIDDK NIH HHS

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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