| The role of vesicoureteral reflux in acute renal cortical scintigraphic lesion and ultimate scar formation. | |
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MedLine Citation:
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PMID: 18804801 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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PURPOSE: We assessed whether differences exist in the rates of acute photon defect and scar formation using dimercapto-succinic acid scintigraphy according to the presence and grade of vesicoureteral reflux. MATERIALS AND METHODS: A total of 389 patients with a first febrile urinary tract infection were enrolled. For all patients ultrasonography, dimercapto-succinic acid scintigraphy and voiding cystourethrography were performed. Dimercapto-succinic acid scintigraphy was performed within 5 days of and 6 months after diagnosis of urinary tract infection. Voiding cystourethrography was performed after the acute phase of urinary tract infection. The rates of acute photon defect and scar formation on dimercapto-succinic acid scintigraphy according to the presence and grade of vesicoureteral reflux were assessed. RESULTS: A total of 125 females and 264 males were included in the study. Of the patients 93 had refluxing urinary tract infection and 296 had nonrefluxing infection. The rate of acute photon defect (74.2% vs 32.1%, p = 0.0001) and the rate of ultimate scar change on followup dimercapto-succinic acid scintigraphy were significantly higher in patients with refluxing urinary tract infection (50% vs 18.3%, p = 0.0001). Positive linear association was noted between reflux grade and acute photon defect by linear association test (p = 0.002). No association was found between reflux grade and scar formation (p = 0.262). CONCLUSIONS: Although vesicoureteral reflux is not a prerequisite for development of acute photon defect and subsequent renal scarring, reflux itself might be an aggravating factor for acute photon defect and scar formation. There seems to be a correlation between reflux grade and frequency of acute photon defect on dimercapto-succinic acid scintigraphy but scar change occurs independently of reflux grade. |
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Authors:
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Mi Mi Oh; Myeong Heon Jin; Jae Hyun Bae; Hong Seok Park; Jeong Gu Lee; Du Geon Moon |
Publication Detail:
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Type: Journal Article Date: 2008-09-20 |
Journal Detail:
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Title: The Journal of urology Volume: 180 ISSN: 1527-3792 ISO Abbreviation: J. Urol. Publication Date: 2008 Nov |
Date Detail:
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Created Date: 2008-10-20 Completed Date: 2008-11-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0376374 Medline TA: J Urol Country: United States |
Other Details:
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Languages: eng Pagination: 2167-70 Citation Subset: AIM; IM |
Affiliation:
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Department of Urology, Korea University Hospital 80, Seoul, Republic of Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Acute Disease Age Distribution Chi-Square Distribution Child, Preschool Cicatrix / pathology, radionuclide imaging Cohort Studies Female Follow-Up Studies Humans Incidence Infant Kidney Cortex / pathology*, radionuclide imaging Kidney Diseases / etiology, pathology, radionuclide imaging* Male Probability Retrospective Studies Risk Assessment Sensitivity and Specificity Severity of Illness Index Sex Distribution Technetium Tc 99m Dimercaptosuccinic Acid / diagnostic use* Urinary Tract Infections / epidemiology, radionuclide imaging* Urodynamics Vesico-Ureteral Reflux / complications*, radionuclide imaging |
| Chemical | |
Reg. No./Substance:
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65438-08-6/Technetium Tc 99m Dimercaptosuccinic Acid |
| Comments/Corrections | |
Comment In:
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J Urol. 2008 Nov;180(5):1884-5
[PMID:
18801528
]
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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