| The role of vasopressin and terlipressin in catecholamine-resistant shock and cardio-circulatory arrest in children: Review of the literature. | |
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MedLine Citation:
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PMID: 21253815 Owner: NLM Status: Publisher |
Abstract/OtherAbstract:
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INTRODUCTION: Arginine-vasopressin (AVP) and terlipressin (TP) are used as rescue drugs for states of shock and cardio-circulatory failure. METHODS: Review to assess AVP/TP as a rescue therapy in children with catecholamine-resistant shock or cardio-circulatory arrest. RESULTS: A total of 31 reports were included (428 patients); sixteen articles were case series, 10 case reports, 3 clinical evaluation studies, one study was a non-blind RCT while one study was a multicentre double-blind RCT. The most common indication for either drug was catecholamine-refractory septic shock (12 reports). Commonly reported responses following AVP/TP administration were a rapid increase in blood pressure, an increase in urine output, and a decrease in serum lactate. In most reports, AVP and TP led to the reduction of catecholamines. The cumulative mortality rate remained high (188/428; 43.9%) despite the use of AVP/TP. CONCLUSIONS: No firm recommendations on the use of AVP/TP in children with severe forms of cardio-circulatory failure can be issued. |
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Authors:
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Sascha Meyer; William McGuire; Sven Gottschling; Ghiath Mohammed Shamdeen; Ludwig Gortner |
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Publication Detail:
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Type: JOURNAL ARTICLE Date: 2011-1-25 |
Journal Detail:
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Title: Wiener medizinische Wochenschrift (1946) Volume: - ISSN: 1563-258X ISO Abbreviation: - Publication Date: 2011 Jan |
Date Detail:
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Created Date: 2011-1-21 Completed Date: - Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 8708475 Medline TA: Wien Med Wochenschr Country: - |
Other Details:
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Languages: ENG Pagination: - Citation Subset: - |
Affiliation:
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Department of Paediatrics and Paediatic Intensive Care Medicine, University Hospital of Saarland, Homburg, Germany, sascha.meyer@uniklinik-saarland.de. |
Vernacular Title:
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Die Rolle von Vasopressin und Terlipressin beim katecholamin-refraktären Schock und Reanimation im Kindesalter: eine Literaturübersicht. |
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From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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