Document Detail


The role of vasopressin in modulating circadian rhythm responses to phase shifts.
MedLine Citation:
PMID:  9786169     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Telemetered body temperature (BT), heart rate (HR), and motor activity (AC) data were collected in vasopressin-containing, Long-Evans (LE) and vasopressin-deficient, Brattleboro (DI) rats. In Experiment 1, the rats were initially exposed to a 12 h/12 h light/dark cycle under ad-libitum feeding and were then subjected to either a phase-advance or phase-delay shift of 6 h. After the phase-advance shift, neither strain adapted; however, after the phase-delay shift, both strains adapted rapidly. In Experiment 2, the animals were subjected to either a nocturnal or a diurnal restricted-feeding paradigm and were then exposed to either a phase-advance or phase-delay shift with synchronized feeding. In the nocturnal restricted-feeding paradigms, both strains rapidly adapted to both shifts. Concerning diurnal restricted-feeding, DI animals readily entrained to the presentation of food in both shifts; whereas, LE animals exhibited a confused rhythmicity. In Experiment 3, animals were subjected to a phase-advance shift, while the time of feeding was held constant. Following the shift, LE animals responded to the onset of the dark at the new time; yet, were still influenced by the presentation of food. The DI animals maintained the preshift circadian pattern and continued to be dominated by the presentation of food. These experiments indicate that circadian rhythms of LE animals are dominated by the light entrainable oscillator (LEO) in ad-libitum feeding and by both the LEO and food entrainable oscillator (FEO) in restricted-feeding. On the other hand, the circadian rhythms of DI animals are dominated by the FEO unless food is provided ad-libitum. The demonstrated role of vasopressin in synchronizing circadian rhythms to the LEO may be of significance in understanding human circadian rhythm disturbances, such as jet lag.
Authors:
H M Murphy; C H Wideman; G R Nadzam
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Peptides     Volume:  19     ISSN:  0196-9781     ISO Abbreviation:  Peptides     Publication Date:  1998  
Date Detail:
Created Date:  1998-12-17     Completed Date:  1998-12-17     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  8008690     Medline TA:  Peptides     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  1191-208     Citation Subset:  IM    
Affiliation:
Department of Psychology, John Carroll University, Cleveland, OH 44118, USA. hmurphy@jcvaxa.jcu.edu
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MeSH Terms
Descriptor/Qualifier:
Animals
Biological Clocks / physiology*
Body Temperature
Circadian Rhythm*
Eating
Food Deprivation
Heart Rate
Male
Motor Activity
Photoperiod
Rats
Rats, Brattleboro
Sleep
Time Factors
Vasopressins / physiology*
Water
Chemical
Reg. No./Substance:
11000-17-2/Vasopressins; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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