| The role of valproate in metabolic disturbances in bipolar disorder patients. | |
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MedLine Citation:
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PMID: 20060174 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Our previous report showed that patients with bipolar disorder (BD) have higher prevalence of hypertriglyceridemia, low high-density lipoprotein cholesterol (HDL) and obesity in Taiwan. To confirm whether the metabolic disturbances is associated with the disease itself or the medications used for treating BD, we further compared the metabolic status among the valproate (VPA) treated BD patients, drug-free BD patients and healthy controls in Taiwan. METHOD: This cross-sectional study included 119 healthy controls and 77 BD patients diagnosed according to the DSMIV-TR criteria in a university hospital. Among the diseased group, 25 remitted BD patients were drug-free (BD-F), and 52 of them were treated with VPA (BD-VPA). Their body mass index (BMI), plasma glucose levels and plasma lipid profiles were measured. RESULTS: Plasma fasting glucose, insulin, total cholesterol, triglyceride, high-density lipoprotein cholesterol, and low-density lipoprotein cholesterol (LDL) levels were significantly different among BD-VPA, the BD-F, and the healthy control groups. Valproate treatment was associated with significant higher plasma insulin, triglyceride, and BMI levels as well as lower fasting glucose and HDL levels. However, these biochemical indexes did not differ significantly between the BD-F and the healthy control groups. CONCLUSION: These results provide further evidence that VPA treatment for BD may increase the risk of metabolic disturbances. The risk may be reduced after discontinuing VPA medication. |
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Authors:
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Hui Hua Chang; Yen Kuang Yang; Po Wu Gean; Hui Chun Huang; Po See Chen; Ru Band Lu |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-01-13 |
Journal Detail:
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Title: Journal of affective disorders Volume: 124 ISSN: 1573-2517 ISO Abbreviation: J Affect Disord Publication Date: 2010 Aug |
Date Detail:
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Created Date: 2010-07-12 Completed Date: 2010-10-29 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7906073 Medline TA: J Affect Disord Country: Netherlands |
Other Details:
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Languages: eng Pagination: 319-23 Citation Subset: IM |
Copyright Information:
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Copyright 2009 Elsevier B.V. All rights reserved. |
Affiliation:
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Institute of Biopharmaceutical Sciences, College of Medicine, National Cheng Kung University, Tainan 70428, Taiwan. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adult Anticonvulsants / adverse effects*, therapeutic use Bipolar Disorder / blood, drug therapy* Blood Glucose / metabolism Body Mass Index Cholesterol, HDL / blood Cholesterol, LDL / blood Cross-Sectional Studies Female Humans Hypertriglyceridemia / blood, chemically induced Insulin / blood Male Metabolic Syndrome X / blood, chemically induced* Middle Aged Obesity / chemically induced Reference Values Risk Factors Taiwan Valproic Acid / adverse effects*, therapeutic use Young Adult |
| Chemical | |
Reg. No./Substance:
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0/Anticonvulsants; 0/Blood Glucose; 0/Cholesterol, HDL; 0/Cholesterol, LDL; 11061-68-0/Insulin; 99-66-1/Valproic Acid |
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