Document Detail

A role for the vagus nerve in the etiology and maintenance of the hyperinsulinemia of genetically obese fa/fa rats.
MedLine Citation:
PMID:  3905650     Owner:  NLM     Status:  MEDLINE    
It is demonstrated that pre-obese Zucker rats, studied before weaning (17 days of age), at a time when they were indistinguishable from lean controls, do hypersecrete insulin in response to glucose or arginine administration when compared to their lean littermates in spite of normal basal insulin levels. When arginine is used as the stimulus, it is shown that pre-obese pups hypersecrete glucagon as well as insulin, the net result of insulin and glucagon oversecretion being probably the observed normoglycemia of these animals. Furthermore, these early substrate-induced increases in pancreatic hormonal secretion could be reduced toward normal values by acute pre-treatment of the pre-obese rats with the cholinergic inhibitor, atropine. It is suggested the parasympathetic nervous system plays a role in genetically obese fa/fa rats in bringing about an early increased substrate-induced insulin release, a defect which could be one of the causes involved in the development of their obesity syndrome. In adult animals, the involvement of the parasympathetic nervous system in insulin oversecretion is less clear probably due to the presence of an increased B cell mass. However, using three different experimental approaches, it could be seen that an increased vagal tone acting at the B cells in obese animals participate to their insulin hypersecretion.
F Rohner-Jeanrenaud; B Jeanrenaud
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  International journal of obesity     Volume:  9 Suppl 1     ISSN:  -     ISO Abbreviation:  Int J Obes     Publication Date:  1985  
Date Detail:
Created Date:  1986-01-21     Completed Date:  1986-01-21     Revised Date:  2014-06-03    
Medline Journal Info:
Nlm Unique ID:  7703240     Medline TA:  Int J Obes     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  71-5     Citation Subset:  IM    
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MeSH Terms
Arginine / pharmacology
Atropine / pharmacology
Electric Stimulation
Glucagon / secretion
Glucose / pharmacology
Hyperinsulinism / etiology*
Insulin / secretion
Obesity / complications*,  genetics
Pancreas / drug effects,  secretion
Rats, Zucker
Vagus Nerve / physiology*
Reg. No./Substance:
0/Insulin; 7C0697DR9I/Atropine; 9007-92-5/Glucagon; 94ZLA3W45F/Arginine; IY9XDZ35W2/Glucose

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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