| A role for the vagus nerve in the etiology and maintenance of the hyperinsulinemia of genetically obese fa/fa rats. | |
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MedLine Citation:
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PMID: 3905650 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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It is demonstrated that pre-obese Zucker rats, studied before weaning (17 days of age), at a time when they were indistinguishable from lean controls, do hypersecrete insulin in response to glucose or arginine administration when compared to their lean littermates in spite of normal basal insulin levels. When arginine is used as the stimulus, it is shown that pre-obese pups hypersecrete glucagon as well as insulin, the net result of insulin and glucagon oversecretion being probably the observed normoglycemia of these animals. Furthermore, these early substrate-induced increases in pancreatic hormonal secretion could be reduced toward normal values by acute pre-treatment of the pre-obese rats with the cholinergic inhibitor, atropine. It is suggested the parasympathetic nervous system plays a role in genetically obese fa/fa rats in bringing about an early increased substrate-induced insulin release, a defect which could be one of the causes involved in the development of their obesity syndrome. In adult animals, the involvement of the parasympathetic nervous system in insulin oversecretion is less clear probably due to the presence of an increased B cell mass. However, using three different experimental approaches, it could be seen that an increased vagal tone acting at the B cells in obese animals participate to their insulin hypersecretion. |
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Authors:
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F Rohner-Jeanrenaud; B Jeanrenaud |
Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: International journal of obesity Volume: 9 Suppl 1 ISSN: 0307-0565 ISO Abbreviation: Int J Obes Publication Date: 1985 |
Date Detail:
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Created Date: 1986-01-21 Completed Date: 1986-01-21 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 7703240 Medline TA: Int J Obes Country: ENGLAND |
Other Details:
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Languages: eng Pagination: 71-5 Citation Subset: IM |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Animals Arginine / pharmacology Atropine / pharmacology Electric Stimulation Glucagon / secretion Glucose / pharmacology Hyperinsulinism / etiology* Insulin / secretion Obesity / complications*, genetics Pancreas / drug effects, secretion Perfusion Rats Rats, Zucker Vagus Nerve / physiology* |
| Chemical | |
Reg. No./Substance:
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11061-68-0/Insulin; 50-99-7/Glucose; 51-55-8/Atropine; 74-79-3/Arginine; 9007-92-5/Glucagon |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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